The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes
Journal Title: Jornal de Pediatria - Year 2019, Vol 95, Issue 2
Abstract
Objective The purpose of this study was to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with type 1 diabetes. Method This case–control study was conducted on 72 children with type 1 diabetes and compared to 48 healthy children, who were age, sex, and ethnicity-matched. The diabetic children were divided according to their glycosylated hemoglobin (A1c %) into two groups: poor and good glycemic control groups. All children underwent full history taking, clinical examination, and laboratory measurement of complete blood count, A1c %, plasma cholesterol, triglycerides, and vitamin E levels and coenzyme Q10 levels in plasma, erythrocytes, and platelets. Results Children with poor glycemic control showed significantly higher plasma vitamin E, coenzyme Q10, triglycerides, low-density lipoproteins, waist circumference/height ratio, cholesterol levels, and lower high-density lipoproteins and platelet coenzyme Q10 redox status in comparison to those with good glycemic control and the control group (p<0.05). Plasma coenzyme Q10 showed a positive correlation with the duration of type 1 diabetes, triglycerides, cholesterol, vitamin E, and A1c %, and negative correlation with the age of the diabetic group (p<0.05). The platelet redox status showed a negative correlation with the A1c % levels (r=−0.31; p=0.022) and the duration of type 1 diabetes (r=−0.35, p=0.012). Conclusion Patients with type 1 diabetes, especially poorly controlled, had elevation of plasma vitamin E and coenzyme Q10 levels and decreased platelet redox status of coenzyme Q10, which may be an indicator of increased oxidative stress.
Authors and Affiliations
Usama Alkholy
Keywords
Related Articles
- EP ID EP497490
- DOI 10.1016/j.jped.2017.12.005
- Views 44
- Downloads 0
Effects of programmed physical activity on body composition in post-pubertal schoolchildren
Objective To assess body composition modifications in post-pubertal schoolchildren after practice of a physical activity program during one school year. Methods The sample consisted of 386 students aged between 15 and 1...
Energy expenditure, growth, and nutritional therapy in appropriate and small for gestational age preterm infants
Objective To evaluate the resting energy expenditure, growth, and quantity of energy and macronutrients intake in a group of preterm newborns. Methods The cohort study was performed with appropriate and small for gestat...
Maple syrup urine disease in Brazil: a panorama of the last two decades
Objective To characterize a sample of Brazilian patients with maple syrup urine disease (MSUD) diagnosed between 1992 and 2011. Methods In this retrospective study, patients were identified through a national reference...
Ultra-processed food consumption in children from a Basic Health Unit
Objectives To evaluate the contribution of ultra-processed food (UPF) on the dietary consumption of children treated at a Basic Health Unit and the associated factors. Methodology Cross-sectional study carried out with...
Chromosomal microarrays testing in children with developmental disabilities and congenital anomalies
Objectives Clinical use of microarray-based techniques for the analysis of many developmental disorders has emerged during the last decade. Thus, chromosomal microarray has been positioned as a first-tier test. This stud...