The correlation between blood lead levels and knee osteoarthritis: a preliminary Egyptian study
Journal Title: International Journal of Clinical Rheumatology - Year 2017, Vol 12, Issue 4
Abstract
Background: Lead is a common ubiquitous environmental pollutant. The increasing prevalence of knee Osteoarthritis (OA) among young patients is suggestive of a possible contribution of environmental factors such as lead. This work aimed to assess the correlation between blood lead and hyaluronic acid levels and degree of knee osteoarthritis among a group of young adult Egyptian patients. Methods and findings: This study was conducted on 90 patients aged 20-50 years old, presented with knee OA. Clinical and radiological assessments of OA severity were performed. Blood samples were collected for estimation of lead and hyaluronic acid (HA) levels. The mean age of the study participants was 36.88±8.96 years. The median blood lead level was 6.35 μg/dl. There was a significant correlation between blood lead level and the severity of knee osteoarthritis either clinically or radiologically. The median serum HA level was 46.95 ng/ml (min-max:10.4-184 ng/ml). A significant positive correlation was found between blood lead and HA levels. Conclusions: it could be concluded that lead represents a potential contributing environmental risk factor for osteoarthritis. Further investigation is warranted to clarify the exact mechanisms involved in the pathogenesis of this disease in relation to various environmental pollutants including lead.
Authors and Affiliations
Reem Khaled Abo-Elmaaty, Rania Hamed Abdel-Rahman, Abeer Abdel-Hamid Fekry, Sahar A. El-Dakroory, Mona Ahmed El-Harouny
Keywords
Related Articles
- EP ID EP603577
- DOI -
- Views 56
- Downloads 0
Small fiber neuropathy as a part of fibromyalgia or a separate diagnosis?
Fibromyalgia (FM) is a chronic disease characterized mainly by widespread pain, fatigue and cognitive disorders. Small Fiber Neuropathy (SFN) is a generalized sensory nerve disorder with structural and functional nerve a...
The test/retest reliability of physical performance measures in osteoarthritis patients
Objectives: There is limited data examining the reliability and consistency of objective measures of osteoarthritis (OA) function. Therefore the aim of this study was to assess their test/retest reliability. Methods: 21...
Genetic markers in HLA region to identify patients with tuberculosis risk, in RA subjects
Objetive: To identify the patients with RA at highest risk of TB, prior to the use of biological therapy antiTNF. Method: We carried out a study of two phases considered three groups, in the first we performed a case and...
The effect of hydroxychloroquine on endothelial dysfunction in patients with rheumatoid arthritis: A doubleblind randomized clinical trial
Aim: The aim of this study was to evaluate the effect of hydroxychloroquine on endothelial dysfunction in rheumatoid arthritis patients by measuring soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble E-Selec...
An unusual presentation of inflammatory myopathy in a patient on natalizumab treatment for multiple sclerosis: A case report and review of myopathological classification of inflammatory myopathy
Acquired immune and inflammatory myopathies (IIMs) are traditionally subdivided into dermatomyositis, polymyositis, inclusion body myositis (IBM) and necrotizing autoimmune myopathy (NAM). Our patient is a 38-year old fe...