The Effect of Soy Isoflavones on the Menopause Rating Scale Scoring in Perimenopausal and Postmenopausal Women: A Pilot Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 9
Abstract
Introduction: Menopause is associated with many unpleasant symptoms which vary in different phases of menopausal transition. Although, Hormone Replacement Therapy (HRT) is considered the most effective mode of treatment for these symptoms, its use is associated with increased risk of breast cancer, endometrial cancer and thromboembolic events. Soy isoflavones are being widely used as a safer alternative to HRT, even though scientific evidence of their efficacy is poor or lacking. Aim: To study the effect of soy isoflavone supplementation on the menopausal symptoms in perimenopausal and postmenopausal women. Materials and Methods: An observational pilot study was done involving 29 perimenopausal and 21 postmenopausal women prescribed 100 mg soy isoflavones for 12 weeks. Menopause Rating Scale (MRS) questionnaire was administered to the patients before starting soy isoflavone therapy and at the end of treatment. Responses were analysed using Statistical Package for Social Sciences (SPSS) software 23.0. Results: Total score of both the groups were comparable at baseline. Among perimenopausal women highest score was given to symptoms of psychological domain. Urogenital symptoms were the worst among postmenopausal women. After 12 weeks of treatment, total scores improved significantly by 19.55% and 12.62% in the perimenopausal and postmenopausal women respectively. The greatest improvement was seen in scores of hot flashes for both the groups and the least improvement was shown by symptoms of urogenital subscale. Conclusion: Soy isoflavone improves the MRS score among both the perimenopausal and postmenopausal women. As they are most effective for somatic and psychological symptoms, their use could be beneficial during perimenopause.
Authors and Affiliations
Marya Ahsan, Ayaz Khurram Mallick
Keywords
Related Articles
- EP ID EP362946
- DOI 10.7860/JCDR/2017/26034.10654
- Views 56
- Downloads 0
A Survey on Nickel Titanium Rotary Instruments and their Usage Techniques by Endodontists in India
Introduction: The preference and usage of nickel titanium rotary instruments varies from individual to individual based on their technique, experience with the rotary systems and the clinical situation. Very limited info...
Internet Technology based Research for Smoking Cessation in India-Hope of a New Era
Abstract Tobacco smoking has been a rampant problem in India since decades. It poses a great burden on the socioeconomic life of the individuals and affects country’s progress. Burden of smoking had been on a rise in Ind...
Mammary Analogue Secretory Carcinoma of Salivary Gland – A Diagnostic Dilemma
Mammary Analogue Secretory Carcinoma (MASC) of salivary gland is a recently described entity with unique morphologic, clinical and genetic characteristics, including the characteristic t(12;15)(p13;q25) with ETV6-NTRK3 t...
Is Interleukin-18 an Early Diagnostic Biomarker in Contrast Induced Nephropathy?
Abstract Introduction: The rise in number of cases of hospital-acquired acute kidney injury in patients undergoing diagnostic and therapeutic procedures by the use of contrast medium is a growing concern among nephrologi...
Pulmonary Functions in Patients with Subclinical Hypothyroidism
ABSTRACT Introduction: Hypothyroidism affects all organ systems of the human body including the respiratory system. Subclinical hypothyroidism is the earliest stage of hypothyroidism and has a high prevalence rate world...