THE EFFECT OF VANCOMYCIN DOSES GREATER THAN 2 GRAMS ON SERUM CREATININE AND VANCOMYCIN TROUGH LEVELS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 8
Abstract
Objective: To assess the effect of vancomycin doses greater than 2 grams on renal function and vancomycin trough levelsMethods: This is a retrospective, pharmacokinetic study performed in a tertiary care level II trauma center. 3579 electronic charts of patients who received vancomcyin at the medical facility between January 2010 and December 2011 were reviewed. Only 30 patients met the inclusion criteria of the study. Included patients were those who were at least 18 years of age who received doses greater than 2 grams of vancomycin for at least 48 hours. Patients in the intensive care units, pregnant or on hemodialysis and were not included in the study. The mean weight for the participants was 154.67 kg.Results: Patients were dosed based on the institution’s vancomycin dosing protocol such as 15-20 mg/kg per dose where the frequency was determined based on the estimated creatinine clearance using cockroft gault equation. A loading dose of 25-30 mg/kg was administered in few cases. Two out of thirty subjects had shown an increase of serum creatinine of ≥ 0.3mg/dL when receiving maintenance doses greater than 2 grams of vancomycin. A Z approximation test was used where a standard error of 0.043 with an α error equal to 0.05 and a 95% confidence interval of (-0.024-0.144) were found. The use of doses greater than 2 grams of IV vancomycin did not show a statistically significance increase in serum creatinine. The two subjects who did have a significant increase in serum creatinine were receiving concomitant nephrotoxins. Conclusion: The use of doses greater than 2 grams of IV vancomycin did not show a statistically significant increase in serum creatinine. Patients whom serum creatinine increased were on other nephrotoxin agents that could have contributed to the acute kidney injury that was seen in these patients.
Authors and Affiliations
Hanine Mansour, Jeffrey A Bush, Michael Brito, Paul Novotny, Cale Courtney, Jordan Mustonen, Kim Towey
Keywords
Related Articles
- EP ID EP579784
- DOI -
- Views 63
- Downloads 0
PREVALENCE AND FACTORS ASSOCIATED WITH OBESITY AMONG ADULT AT THE KAMPUNG KOLAM, EAST COAST MALAYSIAN PENINSULA-A CROSS SECTIONAL STUDY
Objective: This study assesses the prevalence of obesity and its associated factors among adults aged 18 y and above at the Kampaung kolam, Kuala Terengganu, Malaysia.Methods: This cross-sectional survey comprised of a s...
FORMULATION AND IN VITRO EVALUATION OF COMBINED FLOATING-BIOADHESIVE TABLETS OF IMATINIB MESYLATE
Objective: Gastro retentive drug delivery system (GRDDS) pertaining to its attributes like gastric retention time and the extended drug release profile has significantly improved patient compliance. The objective of the...
POTENTIAL ROLE OF CARICA PAPAYA AND THEIR ACTIVE CONSTITUENTS IN THE PREVENTION AND TREATMENT OF DISEASES
Natural products or products from the plant source show pivotal role in the diseases prevention and treatment since ancient. Numerous plants and their ingredients such as Nigella sativa, curcumin, olive and dates fruits...
ALUMINA CATALYST: SYNTHESIS OF NOVEL QUINAZOLINE DERIVATIVES AND THEIR SOLUBILITY INCREASES THROUGH INCLUSION WITH β-CYCLODEXTRIN
Objective: To synthesis a novel methodology of bioactive quinazoline derivatives under greener process to an excellent yields and increases their solubility via inclusion with β-cyclodextrin (CD). Methods: Derivatives o...
DURATION DEPENDENT ANTIAPOPTOTIC EFFICACY OF CAMELLIA SINENSIS (GREEN TEA) ON STREPTOZOTOCIN INDUCED DIABETES LINKED TESTICULAR HYPOFUNCTION IN ALBINO RAT: GENOMIC AND FLOW CYTOMETRIC ASSESSMENT
Objective: The study has been conducted to search out the threshold duration of treatment of ethyl acetate fraction of methanolic extract of leaves of Camellia sinensis (L.) Kuntze at the dose of 100 mg/kg body weight fo...