The efficacy and safety of intravaginal misoprostol for the induction of labor in patients with obstetrical or medical indication for labor induction
Journal Title: Clinical and Experimental Obstetrics & Gynecology - Year 2019, Vol 46, Issue 1
Abstract
Background: Labor induction is becoming one of the most frequent procedures in maternity hospitals. However, the optimal agent for labor induction has not yet been established. Misoprostol, a prostaglandin E1 analogue, is receiving much attention due to its labor induction properties. Objective: The aim of this study was to evaluate the efficacy and safety of 25 and 50 mcg of intravaginal misoprostol, every four hours, for the induction of labor. Materials and Methods: This was a randomized controlled study to compare two different regimens of vaginal misoprostol, in women with obstetrical or medical indication for induction of labor. Participants received either a 25- or 50-mcg dose of misoprostol inserted into the posterior vaginal fornix repeated every four hours (maximum six doses), until adequate labor was established. Close monitoring of uterine activity and fetal heart rate was performed in all patients. Data were collected prospectively on epidemiological, obstetric, and care aspects. Results: Both regimens of misoprostol were effective in the induction of labor and most of the women had normal vaginal deliveries (81.08%). Although the mean time intervals from induction to the onset of active labor, and from induction to vaginal delivery for the 50-mcg regimen were lower, there was no significant difference between the two regimens. There were very few complications, with one case of uterine tachysystole in each treatment regimen. Conclusion: The results of the present study show that both regimens of misoprostol appear to be effective for the induction of labor in patients with indication, with few fetal complications.
Authors and Affiliations
E. Pereira Alves Filho, F. C. Nogueira Arcanjo, A. R. Mesquita Rocha, D. Frade Bernardes, M. H. Frade Bernardes, N. L. Pereira Coutinho
Keywords
Related Articles
- EP ID EP618518
- DOI 10.12891/ceog4364.2019
- Views 50
- Downloads 0
Estrogen replacement therapy is not a recommended therapy for postmenopausal women with coronary heart disease: a meta-analysis
Aim: This study was to investigate the effect of estrogen replacement therapy (ERT) on clinical outcomes for postmenopausal women with established coronary heart disease (CHD). Materials and Methods: The authors conducte...
Superficial cervical scar endometriosis following cone biopsy
Background: Cervical cone biopsy is a common simple surgical procedure for cervical intraepithelial neoplasia and cervical microinvasive carcinoma, with post-surgical bleeding being a common complication. Case Report: A...
En bloc hysterectomy for treatment of symptomatic cervical varix in the early second trimester
The authors present a case of a cervical varix with morbidly adherent placentation treated with total abdominal hysterectomy. A 38- year-old presented at 15 weeks gestation with heavy painless vaginal bleeding and was fo...
The relationship between vitamin D and IVF: a systematic review and meta-analysis
Vitamin D deficiency does not influence IVF outcomes, but is related to lower pregnancy and it is important to provide more reliable evidence on vitamin D in IVF due o the published studies which are strongly contradicto...
Effect of hysteroscopic lysis of intrauterine adhesions in menstruating women on subsequent late proliferative phase endometrial thickness
Purpose: To determine if adhesiolysis of intrauterine adhesions improves or is detrimental to post-operative endometrial thickness in women with normal menstruation. Materials and Methods: Endometrial thickness by sonogr...