Estrogen replacement therapy is not a recommended therapy for postmenopausal women with coronary heart disease: a meta-analysis
Journal Title: Clinical and Experimental Obstetrics & Gynecology - Year 2019, Vol 46, Issue 2
Abstract
Aim: This study was to investigate the effect of estrogen replacement therapy (ERT) on clinical outcomes for postmenopausal women with established coronary heart disease (CHD). Materials and Methods: The authors conducted a meta-analysis using 12 eligible studies. The overall odds ratios (OR) or standardized mean difference (SMD) and their corresponding 95% confidence interval (CI) were calculated. Results: For the incidence of adverse events, significant difference was observed in the occurrence rates of CHD death (OR = 1.166, 95% CI: 1.000-1.360, p = 0.050) and death of any cause (OR = 1.221, 95% CI: 1.057-1.410, p = 0.007) in postmenopausal women with CHD between ERT and placebo groups, whereas there was no significant difference (p > 0.05) in the occurrence rates of CHD events, myocardial infarction (MI), revascularization, unstable angina (UA), venous thromboembolic event, stroke/transient ischemic attack, and congestive heart failure between two groups. With respect to the alterations of other clinical outcomes, the SMD for the alteration of TC level was -0.192 (95% CI: -0.346—0.047, p = 0.015), and a significant difference was detected between the two groups, whereas there was no significant difference (p > 0.05) in the alterations of MLD and TG in patients between the two groups. Additionally, patients treated with ERT had lower LDL and higher HDL levels. Conclusion: This meta-analysis suggests that postmenopausal women with CHD receiving ERT are more likely to suffer from CHD death, death of any cause, lower LDL, and higher HDL and TC levels. Therefore, ERT should not be recommended to postmenopausal women with CHD for the secondary prevention of cardiovascular disease (CVD) clinically.
Authors and Affiliations
Y. Zheng, G. Niu, H. Zhang, W. Lu, Z. Liu
Keywords
Related Articles
- EP ID EP620225
- DOI 10.12891/ceog4485.2019
- Views 47
- Downloads 0
Amenorrhea incidence among symptomatic premenopausal women with uterine fibroids after uterine artery embolization (UAE). Our experience
Objective: To study the impact of uterine artery embolism (UAE) for fibroids on menstrual cycle and cases of amenorrhoea in premenopausal women. Materials and Methods: One hundred forty-five premenopausal women, aged bet...
Quantitative detection of cell-free fetal DNA in peripheral blood of pregnant women during early pregnancy
Objective: This study aimed for the quantitative detection of cell-free fetal DNA (cffDNA) in peripheral plasma of pregnant women, which provides basic data for clinical non-invasive prenatal screening in early pregnancy...
Effects of nicotine exposure on clomiphene citrate induced rats: morphological and immunohistochemical analysis in the ovaries
Objective: The most common use of ovulation induction in clomiphene citrate (CC) administered rats is to investigate whether there is any morphologically and immunohistochemically difference in nicotine exposure between...
Genome-wide association study of recurrent endometriosis related with ovarian cancer
Purpose: Endometriosis is a painful and chronic gynecological disease affecting approximately 10% of reproductiveage women and has an increasing rate of recurrence. However, studies of recurrent endometriosis are lacking...
Personality profile in menopausal women
Purpose of Investigation: Different menopausal conditions may exhibit different personality traits. The Minnesota Multiphasic Personality Inventory (MMPI) responses between naturally menopausal women and surgically menop...