THE LINK BETWEEN DIABETES, DIABETES TREATMENT AND CANCER
Journal Title: Romanian Journal of Diabetes Nutrition and Metabolic Diseases - Year 2011, Vol 18, Issue 4
Abstract
Diabetes mellitus (DM) and cancer are serious diseases, representing a great social burden worldwide and their association has been studied over the years. Several risk factors are common to both DM and cancer and results of epidemiological studies suggest that DM is linked to cancer incidence. However, several types of cancer (e.g. liver, pancreas, endometrial) are more frequent in type 2 DM patients while other neoplasm’s (e.g. breast, colon, rectum, kidney or bladder) represent a smaller risk. Several in vivo and in vitro studies indicate that some anti-diabetic drugs, like insulin analogs, potentate tumor genesis. However, the results of the most of these studies are still under discussion. Some authors suggest that insulin therapy may increase risk for cancer, this phenomenon being mediated by IGF-1R signaling. A mild increase of cancer risk and mortality in DM (mostly type 2) patients has also been suggested. In this review we aim to summarize the current data concerning the association between DM and cancer.
Authors and Affiliations
Laurenţiu Ene, Oana Alexandru, Raluca Budiu, Ada Maria Georgescu, Anica Dricu
Keywords
Related Articles
- EP ID EP150543
- DOI -
- Views 90
- Downloads 0
VALIDITY AND REPRODUCTIBILITY OF A FOOD FREQUENCY QUESTIONNAIRE DESIGNED TO CHARACTERIZE THE DIET OF WOMEN OF CHILDBEARING AGE
Objectives: To test the validity and reproducibility of a food frequency questionnaire (FFQ) administered by interview, consisting of 127 items, developed to characterize the food intake of women of fertile age, in compa...
Photocoagulant Laser Treatment In Diabetic Retinopathy Advantages, Risks, Limits
The present paper proposes to point out the major advantages of laser therapy in diabetic retinopathy, alongside with the presentation of main risks and failure causes of this surgical technique. Preventing blindness in...
HEPATIC FIBROSIS, MEASURED BY FIBROSCANIN A GROUP OF PATIENTS WITH OBESITY
Introduction. Hepatic steatosis is a reversible condition caused by accumulation of triglycerides in liver cells. Non-alcoholic fatty liver disease (NAFLD) can progress to advanced liver disease: fibrosis, cirrhosi...
CORRELATIONS BETWEEN PRO-INFLAMMATORY MARKERS AND GLYCATED HEMOGLOBIN IN TYPE 2 DIABETES PATIENTS
Background and Aim. Markers of inflammation are predictive of diabetic macrovascular complications. In type 2 diabetes, inflammation might be responsible for enhancing insulin resistance and may contribute to the reducti...
FETAL MACROSOMIA IN THE DIABETIC WOMAN
Diabetes mellitus complicates up to 10% of pregnancies, while in Romania the incidence is this under 5%. In most of the cases we are talking about gestational diabetes, while only in 0.1 - 0.3% of the cases, the di...