The Potential Inhibitors in Traditional Chinese Medicine for BCR-ABL T315I Mutation of Chronic Myelogenous Leukemia
Journal Title: UNKNOWN - Year 2018, Vol 8, Issue 4
Abstract
Chronic Myelogenous Leukemia (CML) is a myeloproliferative disorder characterized by the appearance of abnormal proliferation of white blood cells in the Philadelphia chromosome. Current drugs target ABL kinase may have resistance or have risks of serious side effects. We performed molecular docking and 2D-QSAR modeling regarding ABL and its mutant T315I to discover the potential candidate compounds for CML treatment. We present four potent TCM compounds, salvianolic acid C, baicalin, 1,4-dicaffeoylquinic acid, and dihydroisotanshinone I as potential candidates as lead drugs from the TCM compounds. It might have the potential to treat Chronic Myelogenous Leukemia with fewer side effects.
Authors and Affiliations
Yali Xiao, Pei-Chun Chang, Jeffrey JP Tsai
Keywords
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