The Prognostic Impact of Heat Shock Protein-70, IL-23 and IL17A Levels in Colorectal Cancer
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 3
Abstract
Background: Cytokines play a pivotal role in the induction of host immune responses against tumor growth carcinoma and are involved in the development and progression of colorectal cancer in humans. Thus, the aim of the study was to determine Heat shock protein-70 (HSP-70), IL-23 and IL-17A levels in the development and progression of colorectal (CRC) cancer. Methods: A group of 40 patients and 20 healthy volunteers were included in the study. The quantitative determination of serum HSP-70, IL-23 and IL-17A were performed by ELISA. Results: A significant levels of HSP-70, IL-23 and IL-17A in CRC patients compared to the controls was recorded and the highest level was detected in patients with stage D, which was significantly greater than those in stages A, B, and C. Conclusions: HSP-70 and IL-23 levels were significantly elevated in patients’ sera, in contrast to IL-17A, In addition, increased levels were strongly associated with the progression of colorectal (CRC) and these serum cytokine profiles may play a role in tumor development.
Authors and Affiliations
Shahlaa M. Salih
Keywords
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- EP ID EP384994
- DOI 10.9790/3008-110304133135
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