The Relationship between Thyroid Hormone Levels and Body Iron Status in Iranian Hypothyroidism Patients
Journal Title: International Journal of Medical Laboratory - Year 2016, Vol 3, Issue 3
Abstract
Backgrounds and Aims: Thyroid hormones have a crucial physiological role to maintain balance of metabolism of body. Thyroid hormones have an important role in metabolism and proliferation of blood cells. Thyroid gland also has a vital influence on erythropoiesis by induction of erythropoietin secretion and proliferation of erythroid progenitors. In the present study, it was tried to evaluate the effect of hypothyroidism on hematological parameters and also body iron store. Materials and Methods: The research population consisted of 90 subjects divided into two groups: 45 people with hypothyroidism and 45 age-matched healthy individuals. This study checked the amounts of total triiodothyronine (T3), total thyroxine (T4), thyroid stimulating hormone (TSH), and some iron status and hematological parameters. Results: The mean TSH levels were significantly increased in hypothyroid patients compared to control group. On the other hand, the levels of T4 and total iron binding capacity, serum iron, ferritin, Hemoglobin, and Hematocrit were significantly lower in hypothyroid patients compared to control group (p<0.05). However, there was no significant difference in the mean of T3 between hypothyroidism and control. Conclusion: Our data suggest that alterations in thyroid status change serum iron metabolism and hematological index. Hypothyroidism is often associated with anemia,depleted body iron store. As there is no significant clinical manifestation of hypothyroidism at earlier stages with anemia, it is advisable to routinely investigate it for early detection allowing its early management.
Authors and Affiliations
Niko Rostaei Rad, Mahmood Vakili, Javad Zavar-reza, Sona Rezaie, Ahmad Reza Shirvani
Keywords
Related Articles
- EP ID EP212558
- DOI -
- Views 132
- Downloads 0
The Peep of Nanotechnology in Reproductive Medicine: A Mini-review
Nanotechnology has opened a new field in medicine as well as in other sciences. The aim of this study was to seek the capability of nanotechnology for the treatment of various reproductive diseases. In this study, we ana...
Determination of Helicobacter pylori Antigen in Stool Samples and Comparison with Rapid Urease Test in Patients Suspected of Helicobacter Infection
Background and Aims: Helicobacter pylori (H. Pylori) is the microorganism that infects nearly half of word's population. There are several invasive and non-invasive methods for diagnosis of infection. The main objective...
Quantification of Human Chorionic Gonadotropin by Bovine Serum Albumin Nanoparticles
Background and Aims: Some nanoparticles can be used in immunoassays to increase sensitivity. This study aimed to evaluate a novel nano-immunoassay based on bovine serum albumin nanoparticles (BSA NPs). Materials and met...
Association of CYP1A1 IIe462Val (rs1048943) Polymorphism with Breast Cancer in Iranian Women
Backgrounds and Aims: One member of the cytochrome P450 family, CYP1A1, is one of the genes involved in the metabolism of carcinogens and estrogen, which has been identified to be associated with breast cancer, as well....
Evaluating the Coconut Water as a Replacement for the Fetal Calf Serum in Cultivation of Promastigotes of Leishmania Infantum
Backgrounds and Aims: The protozoan parasites of the genus Leishmania can be stated as the causative agents of the various clinical diseases. Fetal Calf Serum (FCS) is the major part of the Leishmania culture media, whic...