The role of osteoprotegerine in pathogenesis of mineral and bone disorders in chronic kidney disease (CKD-MBD)
Journal Title: Annales Academiae Medicae Silesiensis - Year 2014, Vol 68, Issue 4
Abstract
Mineral and bone disorders are the most common pathology in patients with chronic kidney disease (CKD) resulting in the development of accelerated atherosclerosis. Therefore, they are considered as non-traditional cardiovascular risk factors and the cause of increased morbidity and mortality, especially in patients on renal replacement therapy. Osteoprotegerin (OPG) is an important physiological regulator of osteoclastogenesis. As decoy receptor, it binds to the receptor activator of nuclear factor NF- kappaB ligand (RANKL), preventing it from binding to the (RANK) receptor and maturation of osteoclast precursors. The physiological role of OPG, beyond the regulatory function of bone turnover is the inhibition of cell apoptosis induced by inflammatory processes. Elevated levels of circulating OPG is observed in patients with severe atherosclerotic lesions. The experimental studies suggest that OPG does not stimulate, but on the contrary, inhibits the process of atherogenesis. This paper provides an overview of the available literature presenting the role of OPG in the pathogenesis of mineral and bone disorders in CKD. The results of these studies revealed the accumulation of circulating OPG in CKD patients. Additionally, OPG is rather a marker and not a factor involved in the pathogenesis of vascular calcification development in this group of patients.
Authors and Affiliations
Marzena Żelaźnicka-Wilk, Jarosław Wajda, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek
Keywords
Related Articles
- EP ID EP376544
- DOI -
- Views 100
- Downloads 0
Monoclonal antibodies in regulation of signal transduction of Epidermal Growth Factor Receptor (EGFR) pathway in cancer cells
Receptor naskórkowego czynnika wzrostu EGFR (Epidermal Growth Factor Receptor), ze względu na jego ważny udział w patogenezie nowotworów złośliwych, jest obiektem intensywnych badań naukowych ostatnich lat. W wielu typac...
Analiza przypadków przedwczesnego pęknięcia błon płodowych pomiędzy 22 a 33 tygodniem ciąży
WSTĘP: Pęknięcie pęcherza owodniowego pomiędzy 22 a 33 tygodniem ciąży (preterm premature rupture of membranes – PPROM) jest szczególnym scenariuszem klinicznym, kiedy losy noworodka są niepewne, ale jego przeżycie jest...
Diagnostic and therapeutic difficulties in 32-year-old woman with stroke, patent foramen ovale and hereditary thrombophilia – case report
Foramen ovale is a part of foetal circulation that allows blood to flow directly from the right to the left atrium. Patent foramen ovale (PFO) occurs approximately in 20% of the general population. It is suggested that...
Obszary ryzyka w pracy społecznego kuratora sądowego
Zawód kuratora sądowego zaliczany jest do niebezpiecznych. Kurator sądowy w ramach pełnionych obowiązków musi mieć stały kontakt z osobami dozorowanymi, skazanymi prawomocnymi wyrokami na kary o charakterze wol-nościowym...
Estimation of hearing impairment occurrence in patients with Lyme borreliosis – preliminary study
INTRODUCTION: Lyme borreliosis (LB) is the most common tick-borne human disease. The objective of the study was to carry out preliminary evaluation of the incidence of hearing impairments in LB patients. MATERIAL AND MET...