The Utility of Sacubitril/Valsartan in Heart Failure
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Despite the significant advances in the diagnosis and treatment of heart failure (HF), the disease predisposes individuals to a higher risk of re-hospitalization, mortality and morbidity worldwide. Inspite of the presence of several drugs such as angiotensin-converting enzyme inhibitors (ACEI), beta-adrenergic blockers, angiotensin receptor blockers (ARB), and aldosterone antagonists for HF, patients with the illness continue to have a downward spiral due to the disease progression. After more than a decade, a new fixed dose combination has been approved for HF, namely Sacubitril-valsartan. While valsartan is a well-known molecule that blocks angiotensin type 2 receptor, sacubitril is a neprilysin inhibitor. Sacubitril/valsartan an ARNI (angiotensin receptor antagonist/neprilysin inhibitor) has been approved for the treatment of HF with reduced ejection fraction in USA, Europe and Canada. The drug has demonstrated an excellent safety profile, and the drug is purported to become a block-buster for the treatment of HF based on its commendable results in the PARADIGM-HF trial.
Authors and Affiliations
Melvin George, Damal Kandadai Sriram
Keywords
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- EP ID EP251395
- DOI 10.9790/0853-1612088386
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