TOTAL PHENOLIC AND FLAVONOID CONTENTS AND ANTIOXIDANT ACTIVITY OF LANTANA CAMARA AND CUCURBITA PEPO (SQUASH) EXTRACTS AS WELL AS GC-MS ANALYSIS OF LANTANA CAMARA ESSENTIAL OILS
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 1
Abstract
This study aimed to determine total phenolic and flavonoid contents as well as evaluate antioxidant activity of the defatted methanolic extracts of flowers, leaves, stems and certain fractions (dichloromethane, ethyl acetate, n-butanol and water residue) derived from the defatted methanolic extract of Lantana camara and Cucurbita pepo (Squash) leaves besides, the essential oils of L. camara leaves and flowers by using (DPPH, ABTS and TAC assay). The chemical composition of L. camara essential oils was identified by GC-MS analysis. The results exhibited that the defatted methanolic extracts of L. camara (flowers, leaves and stems) have higher phenolic and flavonoid contents as well as antioxidant activity than C. Pepo (Squash) parts. Also, the ethyl acetate fraction of L. camara has the highest phenolic and flavonoid contents as well as the highest antioxidant activity (DPPH; SC50 = 11.82±0.21 μg/ mL, TAC; 290.96±6.71mg eq. ascorbic acid /g extract, ABTS; 94.03±0.25mm Trolox® eq. / 100g extract). There is a positive correlation between the total phenolic and flavonoid contents and the antioxidant activity of the tested extracts or fractions. GC-MS analysis of essential oil of L. camara leaves and flowers revealed the presence of 47 compounds in leaves and 40 compounds in flower. The major compounds in the leaf oil were 7(11) -selinen-4α-ol (14.50%) and cedrenol (6.50%) whereas, the major compounds in flower oil were cedrenol (10.71%) and farnesyl acetone (7.15%).
Authors and Affiliations
Dr. Mortada M. El- Sayed
Keywords
Related Articles
- EP ID EP616997
- DOI -
- Views 202
- Downloads 0
THE EFFECT OF TEMPERATURE AND MOISTURE ON THE PHYSICAL AND CHEMICAL STABILITY OF FUROSEMIDE TABLETS (40 MG) MARKETED IN SYRIA
Stability is an essential factor of quality, safety and efficacy of a drug product. The objective of this study was to investigate the effect of moisture and temperature on furosemide tablets (40 mg) marketed in Syria. T...
A REVIEW ON TRANSDERMAL DRUG DELIVERY SYSTEM
Transdermal drug delivery system is an essential part of novel drug distribution system. The topically administered medications in the form of patches which when applied to the skin deliver the drug .For operative TDDS t...
DESIGN AND EVALUATION OF MUCOADHESIVE BUCCAL BILAYERED TABLETS OF METOPROLOL SUCCINATE
The purpose of this research work was to establish mucoadhesive buccal tablets of Metoprolol succinate in the forms of bilayered tablets. The tablets were prepared using Hydroxy propyl methyl cellulose (HPMC K100M) and P...
THE ROLE OF ADIPONECTINE HORMONE IN OBESE WOMEN WITH POLYCYSTIC OVARY SYNDROME ON OOCYTE AND EMBRYO QUALITY AFTER INTRACYTOPLASMIC SPERM INJECTION PROTOCOL
Both Polycystic ovary syndrome and obesity are associated with specific reproduction health complications, including lower oocyte quality and pregnancy rates in assisted conception cycles which may be due to the endocrin...
EFFECT OF AGING AND IMMERSION IN DIFFERENT SOLUTIONS ON SURFACE PROPERTIES OF DENTURE LINING MATERIAL
Background: Adequate softness and surface integrity are the most important clinical features of soft lining materials. This study was conducted to estimate the effect of aging process and immersion in different solutions...