Toxic And Histopathological Changes of harmful Effect of Diclofenac Sodium on Some Loose Organs in Albino Rats for Twelve Weeks
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 3
Abstract
The present investigation demonstrated the side effect of (I.M.) injection (75 mg/3 ml/ rat/ week) of diclofenac sodium for 12 week on the histological structure of some loose organs of adult rats. During the study no clinical sings were seen and none of the treated animals died during the experiment. This indicates tolerance of the rat to toxicity of the diclofenac sodium. Only histopathological changes were seen after termination and those were in the liver, kidney, heart, pancreas and stomach. These were as follows, vacuolation and degeneration of liver cells, dilated cortical tubules in kidney, degeneration and vacuolation of islet of pancreas, vacuolation of myocardial muscle cells in the heart and erosion and ulceration of the glandular stomach
Authors and Affiliations
Hasan Mohammed
Keywords
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