Toxicants of anticholinesterase action: mechanism of action, clinical signs and existing questions of supply by antidotal therapy
Journal Title: Український журнал сучасних проблем токсикології - Year 2017, Vol 79, Issue 3
Abstract
The article is devoted to the current problem — the deterioration of the current state of chemical safety in Ukraine, the spread of the use of organophosphorus compounds in agriculture, life, pharmaceutical and chemical industry, its negative impact on human health. The present state of chemical safety in Ukraine is analyzed. The main threats of poisoning with anticholinesterase-type agents are determined, characteristics of the mechanism of action, clinical signs and means for the treatment of poisoning with anticholinesterases are given. The authors, on the basis of studying the mechanisms of toxic action, provide suggestions on improving the ways of pharmacological correction, raising the issues of development of drugs and the creation of treatment regimens of intoxication of organophosphorus compounds.
Authors and Affiliations
L. A. Ustinova, N. N. Seredynska, N. V. Kurdil, V. I. Saglo, M. I. Barasii, O. A. Yevtodiev
Keywords
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