TRANSFEROSOME: AN OPPORTUNISTIC CARRIER FOR TRANSDERMAL DRUG DELIVERY SYSTEM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
Transdermal route of drug delivery system has received a great attention in pharmaceutical research and it has already proved its superiority in various respects than oral route, which has a number of problems in drug delivery system. However, the permeation of hydrophilic ioniazable species of drug always has been denied by the intrinsic barrier or stratum corneum for providing local or systemic actions. Transferosomes are ultra deformable vesicles, elastic in nature, which can squeeze itself through a pore and it is more advantageous than the conventional liposome due to its high elasticity, which offers its penetration through narrow constriction without measurable loss. The high permeability of transferosome across the skin also depends on its deformability and intermediate attachment sites for membrane fusion due presence of ripples in vesicles surface. Its infrastructure posses both hydrophilic and hydrophobic moieties together and it can entrap both type of drug. They can act as a carrier for low as well as high molecular weight drugs e.g., analgesics, anesthetics, corticosteroids, sex hormones, anticancer drugs, insulin, gap junction proteins, albumin, etc.
Authors and Affiliations
Malakar Jadupati, Amites Gangopadhyay , Amit Nayak
Keywords
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