Transport and separation through bulk liquid membrane of some biologic active compounds
Journal Title: Ovidius University Annals of Chemistry - Analele Universităţii "Ovidius" Constanţa. Seria chimie - Year 2012, Vol 23, Issue 1
Abstract
Transport through liquid membranes of various chemical species is a viable method for different applications in analytical or technological domain. This paper presents the transport and separation results of two compounds of pharmaceutical importance: salicylic acid and aspirin, using bulk liquid membrane technique. We studied the effect of the feed source and receiving phase pH on the transport efficiency of the two compounds throught chloroform membrane. These results were correlated with speciation diagrams of salicylic acid and aspirin. The speciation diagrams shows that in these pH conditions, for aqueous phase of the membrane system, the two compounds are mostly undissociated form and therefore active for transport. In this system it can be achieve separation of the two compounds, salicylic acid and aspirin, using a suitable complexing agent in the feed source such as Fe3+. In this way salicylic acid forms an inactive complex structure for transport while aspirin crosses the membrane and it is recovered in a percentage of 80% in the receiving phase membrane system.
Authors and Affiliations
ZAHARIA Ionut , DIACONU Ioana , RUSE Elena , NECHIFOR Gheorghe
Keywords
Related Articles
- EP ID EP151510
- DOI -
- Views 78
- Downloads 0
Trace element levels of three mushroom species
The aim of this study was to determine Cu, Fe and Cr contents of three species of fresh mushrooms and canned mushrooms: white and brown champignon ([i]Agaricus bisporus[/i]) and [i]Pleurotus Ostreatus[/i]. Were analyzed...
Electrochemical studies of certain nitro substituted pyrazolin-5-ones
The polarographic behavior of 1-(Toluenyl sulfonyl)-3-amino-4-(2'-nitro aryl hydrazono)-2-pyrazolin-5-one and 1-(Toluenyl sulfonyl)-3-amino-4-(4'-nitro aryl hydrazono)-2-pyrazolin-5-one is investigated in the acidic as w...
Regeneration of used engine lubricating oil by solvent extraction
Huge amounts of used lubricating oils from automotive sources are disposed of as a harmful waste into the environment. For this reason, means to recover and reuse these wastes need to be found. Problems arising from acid...
Simultaneous determination of artificial sweeteners in possible counterfeited wines, using high performance liquid chromatography with DAD detection
Increased use of food, beverages or drugs containing synthetic sweeteners presents a real danger to health, which is why the EU Member States had to establish a system of regular surveys to monitor sweetener consumption....
[i]Sambucus nigra[/i] (L.) liophylised extract as source of direct compression tablets obtaining
The aim of this paper is the valorization of a 10 % anthocyanins elderberries lyophilized extract standardized as cyanidin-3-glucoside in lozenges obtained by direct compression and quality lozenges evaluation according...