β-Thalassemia: From Clinical Symptoms to the Management

Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 5

Abstract

Thalassemia is a single gene disorder is characterised by reduction or absence of beta-globin chain. It is commomest in the Middle East, Southeast Asia, African and some Asian countries including India. Thalassemia has diverse clinical phenotypes. Thalassemia major patients present with severe anemia requiring regular blood transfusion for survival whereas Thalassemia trait is characterized by mild hypochromic, microcytic anemia with elevated HbA2 levels. The prevalence of thalassemia in India 3.3% and a high of 17% in certain communities. There are 30 million carriers and approximately 10000 children are born with the disease every year. Estimated cost for treatment is 1 lacs per child per year which is difficult to afford in developing countries. Management of thalassemics is not only traumatic to the family but also poses a tremendous socio-economic burden on the country making its control and prevention a cause of prime concern. Prenatal diagnosis, of thalassemia offers parents to make reproduction choices and therefore reduce the burden from the society.

Authors and Affiliations

Nitu Nigam, Sanjay Nigam, Monica Agarwal, Prithvi Kumar Singh

Keywords

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  • EP ID EP427977
  • DOI -
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How To Cite

Nitu Nigam, Sanjay Nigam, Monica Agarwal, Prithvi Kumar Singh (2017). β-Thalassemia: From Clinical Symptoms to the Management. International Journal of Contemporary Medical Research, 4(5), 1066-1070. https://europub.co.uk./articles/-A-427977