Validated Spectrophotometric Method for the Assay of Diacerein in Bulk and Pharmaceutical Formulations
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 10
Abstract
The objective of this research was to develop a spectrophotometric method for determination of diacerein in pure form and pharmaceutical formulations. The method was based on the reaction of carboxylic acid group of the drug with a mixture of potassium iodate (KIO3) and potassium iodide (KI) in aqueous medium at room temperature. The reaction followed yellow colored chromogen spectrophotometrically measured absorbance at 352 nm. Beer’s law was obeyed in the concentration range 2-12 µg/ml with molar absorptivity and Sandell’s sensitivity of 2.8339 x 104 L mol/cm and 0.001360 µg/cm2 per 0.001 absorbance units, respectively
Authors and Affiliations
B. M. Gurupadayya , B. M. Bharatheesha
Keywords
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