Vascular permeability- increasing effect of the leaf essential oil of <i>ocimum gratissimum</i> linn as a mechanism for its wound healing property
Journal Title: African Journal of Traditional, Complementary and Alternative Medicines - Year 2005, Vol 2, Issue 3
Abstract
Persistent microvascular hyperpermeability to plasma proteins is a characteristic feature of normal wound healing. Does the leaf essential oil of [i]Ocimum gratissimum[/i] heal wounds by promoting this feature? Evan’s blue dye (20mg/kg body weight) in normal saline was administered intravenously through marginal ear vein of experimental rabbits (n=5). Each animal served as its own control. One hour after Evan’s blue dye administration, 0.1ml each of Ocimum oil, histamine dihydrochloride (30µg/ml) and normal saline were randomly administered by intra-dermal injection at the prepared sites on each of the animals. Increase in vascular permeability was assessed by dye effusion test. Analysis of the differences in vascular permeability between treatment groups showed that, Ocimum oil, in intensity and duration, was significantly (p
Authors and Affiliations
Lara Orafidiya, F. Fakoya, E. Agbani
Keywords
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