A comparative prospective study to assess the efficacy and safety of iron sucrose versus iron sorbitol citric acid in pregnant women with iron deficiency anemia in a tertiary care hospital
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 5
Abstract
Background: The prevalence of iron deficiency anemia (IDA) is 58% among pregnant women in developing countries. According to the recent national guidelines, intramuscular iron sorbitol citric acid (ISCA) complex is one of the firstline drugs for treating moderate IDA in pregnancy. A novel intravenous preparation, iron sucrose promises to be more effective as it causes faster replenishment of iron stores and rapid rise of hemoglobin (Hb). Aims and Objective: The aim of this study is to evaluate the efficacy and safety of iron sucrose versus ISCA complex in IDA of pregnant women. Materials and Methods: A total of 127 pregnant women whose Hb between 7 and 9 g/dl were recruited in the study. They were randomized into two groups to receive iron sucrose (intravenous) and ISCA (I.M), respectively. Hematological parameters were measured at baseline, 4 weeks and 8 weeks of treatment. Results: Mean rise in Hb and serum ferritin from baseline was 3.15 ± 0.08 (P < 0.0001) and 14.1 ± 2.6 (P < 0.0001) at the end of 8 weeks, respectively, with ISCA. Mean rise in Hb and serum ferritin from baseline was 3.36 ± 0.06 (P < 0.0001) and 16.28 ± 3.1 (P < 0.0001) at the end of 8 weeks with iron sucrose. 18% and 42% of pregnant women in iron sucrose and ISCA group experienced side effects, respectively. Conclusion: The rise in hemoglobin and serum ferritin was significant in iron sucrose group with fewer adverse effects. Hence, iron sucrose can be a safe and effective agent in the treatment of IDA in pregnancy.
Authors and Affiliations
Nanthini R, Mamatha K R, Geeta Shivmurthy, Kavitha Kavitha
Keywords
Related Articles
- EP ID EP289487
- DOI 10.5455/njppp.2017.7.0100229012017
- Views 90
- Downloads 0
Escitalopram-induced hyponatremia
Escitalopram is an antidepressant belonging to the class of selective serotonin reuptake inhibitors. It is effective in the treatment of generalized anxiety and major depressive disorders. It also has an off-labeled use...
Neurotrophic effects of turmeric on the memory of the mouse using the Morris water maze test
Background: Turmeric is a yellow-orange spice found mainly in India and other parts of Asia and South America, and is widely used for its medicinal properties. Curcumin, the main part of the turmeric rhizome, may have pr...
Study of visual evoked potentials in patients with type 2 diabetes mellitus and diabetic retinopathy
Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder showing an increasing trend with an increase in complications such as diabetic retinopathy (DR), which can cause blindness. Most patients do not notice...
A comparative study on coagulation profile and neutrophil-lymphocyte ratio in pregnancy-induced hypertension
Background: Hypertension is one of the common medical complications of pregnancy and contributes significantly to maternal and perinatal morbidity and mortality. It is associated with alteration of hematological profile,...
Relation between sleep quality and circulatory levels of inflammatory marker in women of reproductive age group
Background: Alteration in hormonal environment during various phases of a woman’s life contributes sleep disturbances in women. Poor sleep alters the immune system through centrally produced cytokines which is a cause of...