A Prospective Study Comparing Therapeutic Efficacy and Safety of Oral Methotrexate and Oral Prednisone in the Treatment of Generalized Cutaneous Lichen Planus
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 5
Abstract
Lichenplanus is a chronic inflammatory skin disorder.Treatment of generalized cutaneous lichen planus is often difficult and associated with relapse. Recently there have been studies reporting beneficial role of weekly oral methotrexate in lichen planus.Atotal of 30 patients were selected after proper history taking and physical examination and normal laboratory investigation.They were divided into two groups A and B containing 15 patients each. Group A received oral methotrexate 15 or 20 mg weekly up to complete response was achieved or for maximum 20-24 weeks whichever was earlier.Then the dose of methotrexate was tapered by 5mg weekly and stopped.Group B received oral prednisone in dose of 0.5-1 mg/kg daily initially then tapered gradually and given for same duration as in group A. Post treatment follow-up done for 6 months.At the end of treatment 14 out of 15 patients in group A and 11 out of 15 patients in group B showed complete response, chisquare test value was 2.088 and p value≤0. 148.This shows methotrexate has equal efficacy as systemic corticosteroids.There was no relapse in group A but in group B 5 patients had relapse.So,methotrexate has a promising role in lichen planus.
Authors and Affiliations
Sonal Sachan, Shyam Sundar Chaudhary, Kumar Prateek, Melna Jose
Keywords
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- EP ID EP596854
- DOI 10.9790/0853-160502143147.
- Views 89
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