A study of clinical profile of patients with mesenchymal tumour of gastrointestinal tract at SVIMS, Tirupati
Journal Title: Medpulse International Journal of Pathology - Year 2017, Vol 4, Issue 3
Abstract
Background: Although relatively rare, Gastrointestinal stromal tumors (GISTs), make up the largest subset of mesenchymal tumors of the gastrointestinal tract. GIST is known for its wide variability in biological behaviours and it is difficult to predict its malignant potential. The estimated annual incidence is 10-20 cases per million, of which only 20-30% are malignant. Aim and objectives: To study clinical profile of patients with mesenchymal tumour of gastrointestinal tract. Material and methods: It’s a retrospective, hospital record based study of twelve patients affected by GISTs between January 2009 and December 2011 for a period of 03 years. A GIST was defined as a mesenchymal tumor with immunohistochemical positivity for CD 117, the proto-oncogene protein of c-kit. Tumors were considered malignant if they had more than five mitoses per 50 high power fields. Results: In the present study, the age of patients varies between 51 years to 76 years with a mean of 65.3 years and standard deviation of 7.76 years( 65.3 ± 7.76 ). Females affected more than the males. The stomach (66.67%) being the commonest site involved by GISTs followed by small intestines (33.33%). Among the different presenting features, vague upper abdominal pain being the commonest feature encountered. Conclusions: It is important to distinguish GISTs from other mesenchymal tumors of the gastrointestinal tract because of differences in biologic behaviour and treatment strategies. The detection of GIST is based on imaging, endoscopy, histological and immunohistochemical examinations.
Authors and Affiliations
P Durga Prasad, P Vijay Kumar, Rashmi Patnaik, N Rukhmangadha
Keywords
Related Articles
- EP ID EP260210
- DOI -
- Views 96
- Downloads 0
Histopathological study of non-neoplastic and neoplastic skin lesion by punch biopsy in west India - A three year study
Background: Dermatological disorders are common in all countries but the spectrum varies greatly with wide histological variation including both benign and malignant forms. Accurate diagnosis of skin disorders is of utmo...
Clinicopathologic correlation of patients with lupus nephritis
Systemic Lupus erythromatosus (SLE) is an autoimmune disorder of unknown cause that can occur at almost any age, although it affects mostly women in second decade. The annual incidence of SLE is 50 to 70 per one million...
A cytopathological study of salivary gland lesions with histopathological correlation at tertiary health care center
Background: Fine needle aspiration cytology (FNAC) has been widely used as a diagnostic tool for the management of various head and neck lesions. Aims and Objectives: To study salivary gland lesions with histopathologica...
Thyroid lesions: A potential hornet’s nest
Background: Thyroid lesions are the one of the most commonly encountered problems in any hospital in current times. The under lying reasons maybe very many. This study aims at finding the most common presenting lesion in...
Assessment of causes related to anaemia with reference to laboratory criteria
Background: Anaemia, though considered trivial, causes a lot of disability to the patients and if not treated correctly can end up with complication like heart failure. The clinical diagnosis and management of anaemia is...