A study of estrogen and progesterone receptor status in breast carcinoma and its correlation with tumor grading
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2016, Vol 20, Issue 2
Abstract
Introduction: Rise in the incidence of breast cancers in India. Objective: 1. To determine the ER and PR status in unselected breast malignancy cases. 2. Correlate them with modified Bloom and Richardson grading. Material and Methods: This study comprised of 70 cases of breast carcinoma reported in a period of 4 years in the department of Pathology, Gandhi Medical College, Secunderabad. Tissue sections were stained with H and E and histological examination was done. Sections for IHC were taken onto poly-l-lysine coated slides and stained by immunoperoxidase method using ER and PR monoclonal antibodies. Results: Out of 70 cases, 87.88% were IDC (NOS) and two cases (6.06 %) of invasive lobular and mucinous each. Grade was II in 58.49% cases followed by grade III in 20.30 %in remaining 21.21% cases grade was I. Out of 70 cases, 43.42% were ER positive and 39.33% were positive for PR. Correlating with histological grade out of 15 cases of grade I, 86.67 % were positive for both ER and PR. Out of 34 cases of grade II, 44.1% were ER positive and 47.05% were PR positive and in remaining 21cases of grade III, 19.04% were found ER positive and 14.29% PR positive. Conclusion: Histological grading was significantly associated with ER and PR. Hormone receptor immunoreactivity was found to be inversely correlating with histological grade.
Authors and Affiliations
Vijaya Lakshmi K, K Rama Devi
Keywords
Related Articles
- EP ID EP498710
- DOI -
- Views 94
- Downloads 0
Sensory and motor blockade during spinal anaesthesia with 0.75% and 0.5% ropivacaine – A double-blind study
Background: Spinal anaesthesiaproduces intense sensory and motor blockade as well as sympathetic blockade. Ropivacaine is a long-acting regional anaesthetic that is structurally related to Bupivacaine. It is developed fo...
Early Diagnosis of an Unusual Entity- Turbon Tumour
Cylindromas are benign neoplasms that commonly occur as solitary, slow-growing nodules on the head and neck regions, especially the scalp and face. Large variants usually composed of multiple coalescing tumors on the sca...
Clinical Study of Complications in Twin Gestation
A retrospective study of twin pregnancies was done for a period of 6 months from 1st July 2001 to 31st December 2001 at labor and delivery ward admissions at Government Medical College, Nanded. Total 185 cases analyzed f...
Kikuchi’s Fujimoto Disease
Children presenting with cervical lymphadenopathy is common clinical problem.When persistent cervical lymphadenopathy is present then diagnosis of tuberculosis, lymphoma, HIV infection, autoimmune disease is suspected. T...
Comparing the efficacy of 2% diltiazem and verapamil with different concentrations in patients suffering from chronic anal fissure – A randomized double blind clinical trial from a tertiary care center
Background: Benign anorectal disorders are common and increasing in incidence. The decreasing intake in dietary fiber over the 20th century and into the 21st has contributed to a steady rise in preventable anorectal diso...