Adverse effect profile of antileshmanial drugs used in the management of Kala-Azar in paediatrics department in a tertiary care teaching hospital in Bihar
Journal Title: Medpulse International Journal of Pharmacology - Year 2017, Vol 3, Issue 2
Abstract
Problem statement: Viacreal leishmaniasis is one of the major tropical diseases which has been prevalent in India since time immemorial. It’s presence in the Gangetic basin is substantiated by the reference of “KALA-AZAR” in ancient scriptures, to hyperpigmentation of skin. It is the most server from of infection among the spectrum of the disease caused by the protozoa “Leishmania donovani”. Methods: Patients selection and recruitment were done at the department of Paediatrics while the preparatory work, data analysis and archiving was done in the department of pharmacology, M.G.M. Medical College and L.S.K. Hospital, Kishanganj, Bihar. The entire study from patient recruitment data collection, data analysis to reporting took about one year starting from March 2015 to Feb 2016. After obtaining written informed consent, 60 patients between the age 2- 14 years were randomly selected by computer generated random number and were allotted into two groups ; Group A, Patients who had received 30 days course of Amphotericin B, and Patients who had received 30 days course of Miltefosine. Results: In the present study, it was observed that in both the groups, there were no demographic differences but size of spleen, size of liver were decreases significantly on both group but there was no significant differences between two groups. Hemoglobin concentration were raised significantly in both the group but no significant difference was observed between two groups. Blood Urea and Serum creatinine as an indicator of kidney function were measured, it was observe that Blood Urea and Serum creatinine was significantly raised in both the group but there were no significant difference between the two groups. This result indicates both the group Amphotherecin B and Miltefosine are nephrotoxic. Conclusion: From this study it appears, there two drugs Amphotherecin B and Miltefosine are very good drugs for leshminiasis, but one point is kept to in mind both of them are nephrotoxic so continuous monitoring of renal function is to be done regularly. In the course of therapy, if anything goes wrong then drug has to be omitted for short time. If the person are already having kidney renal impairment then these two drugs should be avoided and can be treated by alternative Anti lesminial drug.
Authors and Affiliations
Vidyabrat Rakesh Chaurasiya, Niranjan Sharan
Keywords
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