Analysis of monitoring results of novel coronavirus IgM and IgG antibody levels in apheresis platelets donors and impact on blood safety
Journal Title: Chinese Journal of Blood Transfusion - Year 2023, Vol 36, Issue 9
Abstract
Objective To monitor the positive rates of IgM and IgG antibodies and the changes in S/CO values over time in voluntary blood donors infected with SARS-CoV-2 after recovery, in order to provide theoretical basis and data support for ensuring clinical blood safety. Methods A total of 54 platelet donors who met the inclusion criteria were selected for this study, and 359 blood samples (plasma) from T1 to T7 (at 7 time points, spanning 14 to 15 weeks) were continuously monitored for SARS-CoV-2 IgM and IgG antibodies using fully automated chemi-luminescence method. Results Among 359 blood samples (plasma) from 54 donors, 349 were with valid test results.Eleven donors were tested positive for IgM, with a positive rate of 20.37%, and IgM antibody S/CO value gradually increased during T1-T3, but gradually decreased during T4-T7. Fifty-four donors were tested positive for IgG, with the positive rate of 100%, and the S/CO value of IgG antibody gradually decreased over time. During the period of T1 -T7, there was no significant difference in SARS-CoV-2 IgG antibody S/CO value between gender (male/female) or age group (18-39 years old /40-60 years old). Conclusion The positive rate of SARS-CoV-2 IgG antibody in platelet donors after recovery from SARS-CoV-2 infection was 100% during 2-14 weeks, and the IgG S/CO value gradually decreases over time. The long-term dynamic changes of SARS-CoV-2 serologically specific IgG and IgM antibodies in blood donors are worthy of further study.
Authors and Affiliations
Hui ZHANG, Xinwei WANG, Ruru HE, Zhenxing WEI, Jinheng LIANG, Dong PANG, Limin CHEN
Keywords
Related Articles
- EP ID EP738630
- DOI 10.13303/j.cjbt.issn.1004-549x.2023.09.003
- Views 52
- Downloads 0
Establishment and capacity analysis of Hefei platelet donor bank with HPA and HLA high-resolution results
Objective To establish a platelet donor database with HPA and HLA high resolution results in Hefei area, and to analyze the appropriate pool capacity, so as to provide support for patients with immune PTR transfusion dif...
Establishment and preliminary verification of a highly sensitive nucleic acid extraction method for OBI detection
Objective To establish and verify a new nucleic acid extraction method for OBI detection with large volume and high sensitivity, and apply it in the quantitative determination of OBI samples with low viral load. Methods...
Suspected hemolysis caused by type A therapeutic plasma exchange in a patient with AB subtype miss detected
Objective To investigate the serological changes of blood type and whether hemolytic reactions occurred in a patient with ABw subtype after type A therapeutic plasma exchange(TPE) retrospectively. Methods The ABO blood g...
Study on the distribution of ABO blood group in patients with pancreatic cancer
Objective To investigate whether there is a correlation between the differences in ABO blood group distribution in patients with pancreatic cancer, and to evaluate the relative risk. Methods Patients with pathological di...
Construction of a rapid depression screening model for blood donors in Guangzhou based on decision tree
Objective To investigate the prevalence of depression in blood donors and analyze the related factors, so as to develop a rapid depression screening model for blood donors. Methods A total of 13 015 street whole blood do...