BODE Index Vs FEV1 In Predicting Outcome And Number Of Exacerbations In Stable COPD Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 3
Abstract
The mechanisms underlying COPD exacerbations are poorly understood, and it is a high priority to identify factors that help in predicting their occurrence. Aim and Objectives: The present study was conducted to assess BODE index and GOLD severity staging (based on FEV1) in stable COPD patients, and to assess the utility of BODE index and GOLD severity staging in predicting acute exacerbations and their outcomes in the following one year. It is a hospital based prospective observational study done from September 2014 to November 2016 at Government Hospital for Chest and Communicable Diseases, Andhra Medical College, Visakhapatnam, Andhra Pradesh. Results:100 stable COPD patients were enrolled and were followed up for a period of one year or until their death whichever was earlier. 6 patients were lost to follow-up. Out of 94 patients; 23.40% had a BODE index of 0-2, 28.72% had a BODE index of 3-4, 20.21% had a BODE index of 5-6 and 27.67% had a BODE index of 7- 10. Out of the 94 patients, 12.76%, 20.21%, 37.23% and 29.80% were categorized into GOLD stage 1, 2, 3 and 4 respectively. 38.29% of patients experienced at least one exacerbation, out of which, 5.31% of were managed with OP-based treatment. The remaining 32.97% of patients were hospitalized, of which, 12.76% succumbed to death. BODE index seems to be a better predictor of exacerbations (AUC=0.951) than FEV1 (AUC=0.794), with higher specificity rate. BODE index predicts OP based management of exacerbations better than FEV1 (AUC -- 0.916 vs 0.771). BODE index was also found to be a better predictor of hospitalization rates when compared to FEV1 (AUC—0.916 vs 0.771). BODE index was found to be a significant predictor of mortality with a AUC of 0.884 (p<0.0001) when compared to FEV1 (p=0.1379). Conclusion: BODE index and FEV1 were predictors of number of exacerbations, OP-based management and hospitalizations, but BODE index was found to be a better predictor than FEV1. BODE index was also found to predict outcomes in terms of mortality unlike FEV1.
Authors and Affiliations
Dr. Naga Lakshmi Katragadda, Dr. J. Kundan Raja, Dr. K. Venkata Ramana, Dr. K. V. V. Vijaya Kumar, Dr. CH. R. N. Bhushan Rao, Dr. G. Samba Siva Rao
Keywords
Related Articles
- EP ID EP369101
- DOI 10.9790/0853-1703051823.
- Views 101
- Downloads 0
Study of Cardiovascular Manifestations of Rheumatoid Arthritis and Correlation with Disease Duration and Severity
Aims and objectives: Rheumatoid arthritis is a systemic chronic inflammatory disorder of unknown etiology that primarily involves synovial joint, and secondarily involves various organ systems. Involvement of cardiovascu...
Role of Serum Leptin and its association with Malondialdehyde in Type 2 Diabetic Patients
Background: Leptin is a hormone produced by adipose tissue that regulates a number of physiological processes and behaviors including appetite, body weight, neuroendocrine functions and glycaemia. These effects are media...
Dermatoglyphics In Congenital Heart Diseases In Children
Dermatoglyphics is the scientific study of fingerprints, epidermal ridges and different patterns of epidermal ridges. Dermatoglyphs are the patterns or configurations of epidermal ridges on polar aspects of hand and feet...
Central Cemento-Ossifying Fibroma of Mandible Mimicking Residual Cyst.A Treatment Protocol For Small, Asymptomatic Radiolucencies in oral Cavity.
Presenting an unusual case of asymptomatic central cemento-ossifying fibroma in missing first mandibular molar region (measuring about 1cm in its maximum dimension) discovered incidentally on routine radiographic examina...
Role of Rectal Misoprostol Versus Intramuscular Oxytocin In The Active Management Of Third Stage Of Labour.
Objectives: Atonic postpartum hemorrhage accounts for 80% of cases of postpartum hemorrhage and active management of third stage of labour has become a central component of postpartum hemorrhage reduction strategies. Thi...