Breath analysis as a diagnostic tool for lung cancer
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2017, Vol 6, Issue 1
Abstract
The early diagnosis of lung cancer is key to effectively treating this common and deadly disease. In this review we consider whether non-invasive breath-based detection of volatile biomarkers offers a means to screen populations for the presence of the disease. We find that many potential volatile cancer biomarkers have been reported, including some in multiple studies, and that many are biologically plausible. The field lacks prospective studies, however, which are needed to determine whether such markers are of use for the detection of lung cancer in its pre-symptomatic stages. This,and a lack of knowledge about the various endogenous and exogenous sources of such potential cancer markers, hampers the clinical development of this testing paradigm despite its undeniable appeal. Further work is therefore required before any firm conclusions can be drawn regarding the utility of breath analysis for the diagnosis of lung cancer.
Authors and Affiliations
Randa H. Babgi| Northern Ontario School of Medicine and Department of Biology, Lakehead University, Thunder Bay Ontario, Canada., Brian M. Ross| Northern Ontario School of Medicine and Department of Biology, Lakehead University, Thunder Bay Ontario, Canada.
Keywords
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