Changes in integral indicators of the functional state of experimental animals with the long-term introduction of cadmium chloride and nanoparticles of sulfide cadmium of different sizes
Journal Title: Український журнал сучасних проблем токсикології - Year 2017, Vol 79, Issue 3
Abstract
The purpose of the study was a comparative assessment of the integral indicators of the functional state of experimental animals under conditions of prolonged exposure to cadmium chloride and nanoparticles (NP) of cadmium sulfide of different sizes. Materials and Methods. The studies were carried out on male rats of the mature age of the Wistar line weighing 160–180 grams, which were injected intraperitoneally with cadmium chloride (CdCl) and cadmium sulfide (CdS) nanoparticles with a size 4–6 nm and 9–11 nm in a dose of 0,08 mg/kg/day in terms of cadmium. The body weight was measured weekly. The weight of the internal organs and the muscular endurance measured by the duration of retention time on the pole was evaluated after 30 injections (1,5 months), after 60 injections (3 months), and after cessation of introduction. Results. CdCl2 and NP CdS caused a decrease in the average body weight and body weight gain in comparison with control animals. NP CdS caused a mentioned decrease earlier than CdCl2, but under the influence of CdCl2, these changes were more pronounced. In animals, after the introduction of cadmium compounds, were observed an increase in the relative mass of the brain, liver, spleen, thymus, a decrease in lung mass. There were also observed an increase in the relative mass of the heart and kidney after 30 and 60 injections and their decrease in the post-exposure period. The greatest changes in the weight of the organs where caused by CdCl2, while the smallest ones where caused by NP CdS with the size of 9–11 nm. Reduction of muscular endurance of rats after 30 injections was most pronounced when exposed to NP CdS in size of 4–6 nm. But, in a period after 60 injections and in the post-exposure period, the reduction of muscular endurance was most pronounced with CdCl2 exposure.
Authors and Affiliations
O. L. Apykhtina
Keywords
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