Comparison of Three Different Antibiotic Protocols Used as Prostate Biopsy Prophylaxis in Terms of Infectious Complications
Journal Title: The Bulletin of Urooncology - Year 2020, Vol 19, Issue 2
Abstract
Objective: Development of urinary infection and sepsis following prostate biopsy procedure is the main problem. Despite use of antibiotic prophylaxis, which becomes a routine procedure in prostate biopsy, urinary infection and sepsis may significantly be observed. Furthermore, there is no consensus in terms of the type and duration of prophylaxis. This study aimed to compare the incidence of infectious complications, which developed during 3 different prophylaxis protocols used in our institution. Materials and Methods: Four hundred and eighteen prostate biopsy procedures performed in our institution between 2010 and 2017 were evaluated retrospectively. Patients were divided into 3 groups based on their prophylactic antibiotic protocols. First group patients (n=136) were given ciprofloxacin and gentamicin 80 mg. Second group patients (n=180) were given cefpodoxime and gentamicin 80 mg. Third group patients (n=102) were given cefpodoxime and gentamicin 160 mg. Three groups were compared in terms of post-biopsy infectious complications. SPSS 20 statistical program was used for data evaluation. Results: There was no statistically significant difference between the groups in terms of age, prostate specific antigen level and prostate volume. Urinary tract infection following the prostate biopsy was seen in 11 (8.1%) patients in group 1, 8 (4.4%) patients in group 2 and, 2 (1.9%) patients in group 3. Five of these patients were hospitalized due to deterioration of their overall health status and fever. When 3 groups were statistically compared, infection incidence was significantly different between the first and the third group (p<0.05). Conclusion: Bacterial resistance against fluoroquinolones is particularly increasing day by day. Fluoroquinolone resistance in Escherichia coli strains in our country is reported between 39-63%. In this study, infectious complications were found to be less in cefpodoxime plus gentamicin 160 mg prophylaxis, when compared to ciprofloxacin plus gentamicin 80 mg. Replacing quinolones with cefpodoxime and gentamicin in the antibiotic prophylaxis protocols used before prostate biopsy can minimize risk of infection.
Authors and Affiliations
Aşkın Eroğlu, Şahin Kılıç
Keywords
Related Articles
- EP ID EP685428
- DOI 10.4274/uob.galenos.2019.1319
- Views 161
- Downloads 0
What is the Prostate Specific Antigen Cut-off Value to Detect Metastases in Ga-68 Prostate Specific Membrane Antigen Ligand Positron Emission Tomography/ Computer Tomography Imaging for Intermediate and High-risk Prostate Cancer?
Objective: The aim of this study was to detect a prostate specific antigen (PSA) cut-off value for metastases, and prevent unnecessary use of Ga-68 prostate specific membrane antigen (PSMA) ligand positron emission tomog...
Renal Angiomyolipoma: A Clinicopathological Study of Seven Cases and Review of the Literature
Objective: Renal angiomyolipomas (AMLs) are mesenchymal kidney tumours that have triphasic histology. This study aimed to present the clinical, pathological and immunohistochemical features of seven AML cases along with...
The Role of Adrenal Cortex-Sparing Surgery for Bilateral Masses in Three Cases
Pheochromocytoma are the functional adrenal lesions originating from the chromaffin cells. For the cases of pheochromocytoma observed in multiple endocrine neoplasia Type 2 and Von Hippel syndrome, the bilateral adrenal...
Transurethral Resection of the Bladder Tumor Success Rates of Surgeons and Possible Causes of Differences Between Locals and Refugees
Objective: In our study, we examined the success rates of our surgeons and the criteria that define the success, and tried to reveal the possible causes of the differences in the success rates of transurethral resection...
Management of Patients with Urological Cancers in Turkey during the COVID-19 Pandemic: Recommendations of Uro-oncology Association
Coronavirus disease-19 (COVID-19) has been declared as a pandemic by the World Health Organization. The number of cases has increased over time in correlation with the increasing number of testing worldwide. In order to...