Contraceptive Vaccines

Journal Title: Актуальна інфектологія - Year 2014, Vol 2, Issue 1

Abstract

Researches to develop vaccines with contraceptive effect are being carried out since the 1920s. Since 1972, the contraceptive vaccines are one of the priority programs of the World Health Organization (WHO Special Programme of Research, Development and Research Training in Human Reproduction). Rockefeller Foundation participates in implementing the program. Openly declared objective of creating such vaccines — the regulation of the population in the Third World countries. There are currently three main directions of contraceptive vaccine design: 1) vaccines targeted at blocking the production of gametes; 2) impairing their function; 3) violating the fertilization process. Contraceptive vaccines for more than 10 years are widely used to reduce fertility and castration of wild and domestic animals. In the commercial realization there are veterinary vaccines Equity®, Improvac®, GonaCon®, Repro-BLOC (based on gonadotropin-releasing hormone); SpayVac™ and IVT-PZP® (based on zona pellucida antigens). Clinical studies have shown effective contraceptive action (in women) of vaccines, in which human chorionic gonadotropin is used as an antigen. At the same time, there are found the side effects of such vaccines: for vaccines containing gonadotropin-releasing hormone and luteinizing hormone as antigenic components — castration, impotence; for vaccines containing follicle stimulating hormone — oligospermia; zona pellucida antigens — irreversible oophoritis. This paper discusses approaches to detection of sterilizing components in vaccines intended for mass prevention of infectious diseases, not reported by manufacturers, and the consequences of their use. Hidden use of contraceptive vaccines, which already took place, can be detected: 1) by the presence of antibodies to their antigenic components (in unvaccinated by contraceptive vaccines people such antibodies do not exist, except infertility cases); 2) by change in the hormonal levels of the vaccinated patients; 3) by malfunction and histopathological changes in the reproductive organs.

Authors and Affiliations

M. V. Supotnitsky

Keywords

Related Articles

Intussusception in Children in the Practice of the Pediatrician Infectious Disease Specialist

The patient’s destiny often depends on the pediatrician infectious disease specialist’s ability to appraise the abdominal pain. In this article we analyzed the incidence of development of the intussusception in children...

About the Influence of Bacterial Vaginosis on the Reduction of Female Reproductive Function

Evaluation of the influence of the bacterial vaginosis on the reduction of female reproductive function is given in the article. It has been established that the presence of the bacterial infection requires complete comp...

The prevalence of cryptosporidiosis in children with diarrhea in Donetsk region, Ukraine

An urgent task is to reduce the social and medical burden of protozoal intestinal diseases caused by apicomplexan parasites of the genus Cryptosporidium. This justifies the need to study their prevalence among high-risk...

Ways of Optimization of Specialized Help to HIV-Infected Pregnant Women in Lugansk Region

Article deals with topical issue of modern obstetrics — course of pregnancy, delivery and postnatal period in HIV-infected women. We studied the course of pregnancy and incidence of the extragenital diseases in HIV-infec...

Selery medicinal plants in the Donbas

The performed studies determined the real number of species of medicinal plants in Apiaceae family growing on the Donbass territory. The study of literature and conducted field experiments revealed the presence of 41 spe...

Download PDF file
  • EP ID EP224073
  • DOI -
  • Views 151
  • Downloads 0

How To Cite

M. V. Supotnitsky (2014). Contraceptive Vaccines. Актуальна інфектологія, 2(1), 67-89. https://europub.co.uk./articles/-A-224073