Correction of mexidol metabolic disorders in experimental pulmonary emphysema
Journal Title: Туберкульоз, легеневі хвороби, ВІЛ-інфекція - Year 2018, Vol 0, Issue 3
Abstract
Objective — to study the effectiveness of mexidol on the lipid peroxidation system/antioxidant protection in experimental pulmonary emphysema (PE). Materials and methods. The study is undertaken on 58 mature white rats weighing 180—200 g. The model of papainic emphysema in animals was reproduced by a single intratracheal injection under light ether anesthesia with 0,5 ml of papain solution at doses of 50 mg/kg, 75 mg/kg and 100 mg/kg of body weight. For 2 weeks after the administration of the papaini to animals, mexidol was administered at a dose of 25 mg/kg intramuscular every day. The amount of MDA and the activity of glutathione-dependent enzymes were determined. Results and discussion. Indices of the oxidant-antioxidant system in rat’s blood with experimental PE depending on the dose of papain and influence on them of mexidol were investigated. It was found that in 2 weeks after PE modeling at all doses of papain, there was a violation in the lipid peroxidation system/antioxidant protection: a significant increase in the amount of MDA in erythrocytes and a decrease in the activity of the main glutathione-dependent enzymes. It has been proven that the use of mexidol for therapeutic purposes, regardless of the dose of papain, leads to a decrease in the intensity of lipid peroxidation processes, an increase in the activity of GT, GR and GPO enzymes. Conclusions. The revealed metabolic disturbances in experimental PE are subject to correction by mexidol. Using of mexidol for therapeutic purposes helps to reduce the concentration of lipid peroxidation products, the activation of glutathione-dependent enzymes in the blood.
Authors and Affiliations
V. M. Zhadan, V. I. Korzhov
Keywords
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- EP ID EP421397
- DOI 10.30978/TB2018-3-26
- Views 92
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