DEVELOPMENT AND EVALUATION OF CARBOPOL BASED SUATAINED RELEASED MATRIX TABLETS OF TRAMADOL HYDROCHLORIDE
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2017, Vol 7, Issue
Abstract
Abstract In the present investigation an attempt has been made to increase therapeutics efficacy, reduce frequency of administration and improve patient compliance by developing Sustained release matrix tablets of tramadol hydrochloride using carbopol as rate controlling polymer. Total four formulations ware prepared by using different drug:polymer concentration ratio and subjected to various precompression and post compression parameters. The results ware found with in pharmacopoeial standards for all formualtions. Among the formulation tablets of batch F3 found optimized showed sustained drug release for 12 h. When these dissolution profiles were subjected to various kinetic release investigations and it was observed that the mechanism of drug release was diffusion controlled with a minor contribution from polymeric relaxation. It was found that optimized formulation F3 showed no significant change in physical appearance, drug content, hardness and in vitro dissolution pattern after storage at 45 °C/75% RH for three months. From the study it was concluded that use of carbopol is good choice as rate controlling polymer for the preparation of sustained release tablets.
Authors and Affiliations
R. S. Radke*, N. S. Bhajipale
Keywords
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