Diagnostic and prognostic value of AgNOR study in radiotherapy treated squamous cell carcinoma of the cervix
Journal Title: Medpulse International Journal of Pathology - Year 2017, Vol 3, Issue 3
Abstract
Background: Carcinoma Cervix is the second most common cancer worldwide especially in peri-menopausal period. AgNOR proved to be a sensitive marker to predict the prognosis of the patient treated with radiotherapy. The present study was undertaken to confirm the diagnosis before radiation to access the prognosis at consecutive intervals of 4 weeks and 8 weeks with special attention to the nucleolar changes. Material and Methods: This study included 50 Carcinoma Cervix patients and 25 controls. The Cervical and Vaginal smears collected from controls and from patients prior to radiation therapy and after 4 and 8 weeks after radiotherapy were subjected to AgNOR staining. Results: The AgNOR count/cell has reduced from 3.76 to 3.2 and 2.67 (after 4 weeks and 8 weeks of radiotherapy in Well differentiated squamous cell carcinoma. However, in Moderately differentiated squamous cell carcinoma the reduction is so impressive from a mean of 3.84 to 2.82 to 2.19 (after 4 weeks and 8 weeks of Radiotherapy). Poorly differentiated squamous cell carcinoma also shows a reduction from 4.12 to 3.35 and 2.97. Conclusion: AgNOR count is a simple efficient and inexpensive method which can be used as an adjunct to routine cytology for diagnosis of cervical carcinoma especially in doubtful cases and also used as a prognostic indicator.
Authors and Affiliations
Saraswathi D, Sathiyabama D
Keywords
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