Efficacy and Tolerability of Fixed Dose Combination Valsartan/Amlodipine to Achieve Blood Pressure Target in Iraqi Hypertensive Patients
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2011, Vol 6, Issue 3
Abstract
Background Fixed dose combinations (FDCs) are one of the options for improving blood pressure (BP) goal attainment. However, it has not been studied previously in Iraqi patients. Objective The aim of the study is to evaluate the efficacy and tolerability of FDC valsartan/ amlodipine (Val/Aml) in a group of Iraqi hypertensive patients. Patients and Methods One hundred and eighteen hypertensive patients were recruited from a health centre, male were 49 and female were 69 with a mean age of 49.1 years. In patients whose BP was not controlled on previous antihypertensive therapy, FDC of Val/Aml at a dose of 160/5 mg were given, and allowed to be up titrated to 160/10 mg once daily with or without hydrochlorothiazide of 12.5–25 mg. Patients were followed for a minimum of 12 weeks. The efficacy and tolerability of this medication were studied among the study group. Results Among the study group, 95 patients (80.50%) (P < 0.001) reached their BP target [<140/90 mmHg for uncomplicated hypertension, (<130/80 mmHg for patients with diabetes)] over the 12-week study period; 24 patients (20.33%) who failed to reach BP target [19 patients (16.1%) were lost to follow up, two patients (1.69%) discontinued their treatment due to medication side effects (one patient had lower limb edema, the other patients had dizziness) and three patients (2.54%) were non-compliant to the treatment plan]. Conclusion Treatment with the FDC Val/Aml was associated with significant reductions in systolic BP (SBP) and diastolic BP (DBP), and a significant increase in the BP control rate with an excellent tolerability profile.
Authors and Affiliations
Faiz Rashid Abayechi
Keywords
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