EVALUATION OF NEPHRO PROTECTIVEACTIVITY OF METHANOLIC EXTRACT OF SEEDS OF VITIS VINIFERA AGAINST RIFAMPICIN AND CARBONTETRA CHLORIDE INDUCED NEPHRO TOXICITY IN WISTAR RATS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
The Objective of the study was to investigate the nephroprotective activity of methanolic extract of seeds of Vitisvinifera (family:vitaceae) against rifampicin induced and carbontetrachloride induced kidney damage in rats.Male albino wistar rats (150-250gm) were selected and divided in to six groups of six animals each. Group 1 served as normal control, group 2 served as positive control, group 3 served as standard, group 4 was treated with MEVV (low dose) and group 5 was treated with MEVV (high dose). The same grouping was followed for both models (rifampicin and carbon tetra chloride). Inducing agents are given 3 days once for two weeks to induce nephrotoxicity. The results are evidenced on the basis of physical, biochemical and histological parameters. Oneway analysis of variance followed by tukey’s multiple comparison tests were used for statistical analysis.Rifampicin and carbontetrachloride produced significant changes in physical (decreased liver and body weight), biochemical (increased levels of total protein, uric acid, urea, and creatinine), and histological parameters in rats. Pretreatment with MEVV and standard drug cystone significantly prevented the physical, biochemical and histological changes produced by rifampicin and carbon tetrachloride toxicity. Results of the present study suggest that MEVV has a significant nephroprotective activity probably by acting against free radicals.
Authors and Affiliations
Kalluru Bhargavi, N Deepa Ramani, Janarthan M, Durraivel S
Keywords
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