PREPARATION OF IMMEDIATE RELEASE ATORVASTATIN AND SUSTAINED RELEASE MATRIX TABLETS OF GLICLAZIDE USING RETARDANT: HYDROXYPROPYL METHYL CELLULOSE
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 4
Abstract
In the present work an attempt has been made to formulate tablet containing immediate release Atorvastatin and sustained release Gliclazide using retardant namely hydroxypropyl methyl cellulose. Two different grade of hydroxypropyl methylcellulose in different concentrations were used. In the preformulation study, compatibility evaluation was performed which implies that drugs, excipients and polymers are compatible with each other. The formulation of tablets was done by using wet granulation technique which was found acceptable. All the formulations were subjected to various evaluation studies. The results are in accord with the marketed product.
Authors and Affiliations
Vinod Raghuvanshi, Jayakar B, Debjit Bhowmik, Harish G, Dureivel
Keywords
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