Evaluation of Serum Cystatin C in Acute Kidney Injury
Journal Title: International Journal of Medical and Health Sciences - Year 2016, Vol 5, Issue 2
Abstract
Background: Serum Creatinine, widely used in diagnosing the presence of acute kidney injury, is a suboptimal biomarker. The purpose of our study was to measure serum Cystatin C in patients of acute kidney injury and to correlate with the serum Creatinine and estimated glomerular filtration rate (eGFR). Methods: The study was conducted in patients of acute kidney injury over one and a half year period. Serum Cystatin C was measured in each case at the time of initial work up for diagnosis of acute kidney injury and results were correlated with the simultaneously taken serum Creatinine and with eGFR estimated by four variable MDRD and CKD-EPI equation based on serum Cystatin C and serum Creatinine. Results: Study included 105 patients of acute kidney injury. The mean age of patients was 44.0±16.2 years. The male to female ratio was 3:1. Medical conditions constituted 88% of patients and septicaemia (51%) was the most common precipitating factor for acute kidney injury. The mean values of serum Cystatin C and serum Creatinine were 2.98±1.64 mg/L and 3.8±2.5 mg/dL respectively. A positive correlation was seen between serum Cystatin C and serum Creatinine. A good correlation was observed with e GFR. On multivariate logistic regression analysis it was seen that with increase in serum Cystatin C, serum Creatinine and age, there would occur a decline in GFR. Conclusion: Serum Cystatin levels are elevated in patients of acute kidney injury. There is a significant correlation of serum Cystatin C with serum Creatinine and estimated GFR.
Authors and Affiliations
Gurbhej Singh,Harminder Singh Pannu, Jashan Sandhu,Jasvinder Singh Sandhu,Navjot kaur Bajwa, Suman Sethi, Simran Kaur
Keywords
Related Articles
- EP ID EP39950
- DOI -
- Views 305
- Downloads 0
Serum Gamma Glutamyl Transferase levels in Obese South Indian adults with reference to atherogenic lipid risk factors and lipid peroxides
Background: Obesity has reached epidemic proportions especially in South India. In recent years, Waist circumference (WC), which reflects central obesity, has been regarded as an independent predictor of risk. Generati...
A Study of Serum Calcium, Magnesium and Phosphorous Level in Hypothyroidism Patients
Introduction: Hypothyroidism is one of the most common forms of thyroid dysfunction resulting from the deficiency of thyroid hormones. Mineral metabolism is frequently disturbed in thyroid dysfunctions. Previous studies...
Double toothed mandibular third molar – A rare anomaly – case report
Abberantmorphoanatomy of tooth are not uncommon, like fusion,gemination, concresence, dilacerations, talons cusp, dens in dente, dens evagenatus, taurodontismand supernumerary tooth. But gemination or fusion of mandibul...
Examining the liver – Revisiting an old friend
In the current era of medical practice, super saturated with investigations of choice and development of diagnostic tools, clinical examination is a lost art. In this review we briefly discuss important aspects of exami...
Pre-stroke statin use was associated with lower risk of in-hospital death in nonthrombolysed patients
Background: Prior studies suggested that statins might have a neuroprotective effect in patients with acute ischemic stroke. The aim of this study was the evaluation of the short-term effects of statins following ischem...