Features of Severe Bronchial Asthma Phenotypes in School-Age Children Predisposed to Overweigh
Journal Title: Міжнародний ендокринологічний журнал - Year 2015, Vol 5, Issue 69
Abstract
One of the aspects of inadequate control of severe bronchial asthma (BA) is its phenotypic heterogeneity. Although the relationship between obesity and BA is certain, the mechanism of this phenotype of the disease is poorly understood. The objective of the study was to improve the efficiency of basic treatment for severe BA in school-age children predisposed to overweight based on an analysis of indicators of control, inflammatometry and spirometric characteristics. In a pulmonary department of regional clinical hospital (Chernivtsi), there were examined 18 children predisposed to overweight, whose body mass index exceeded the limits of 95% confidence interval (21.7 kg/m2) (I clinical group). Control group consisted of 39 patients with severe BA, who are not predisposed to overweight. It is proved that a predisposition to overweight in children with severe persistent BA adversely affect the indicators of achieving disease control. The lower efficacy of basic treatment in children predisposed to overweight is established that is due to a significantly greater share of school-age children with neutrophilic nature of bronchia inflammation in this group and airway hypersensitivity to histamine.
Authors and Affiliations
L. A. Ivanova
Keywords
Related Articles
- EP ID EP219675
- DOI -
- Views 67
- Downloads 0
Efficiency of Аdaptol in Comprehensive Treatment of Patients with Thyrotoxicosis Syndrome
Objective — to study Adaptol efficiency in patients with diffuse toxic goiter (DTG) of varying severity with deviations in the emotional sphere without expressed psychoorganic disorders, as well as impact of the drug on...
Correction of bone remodeling disorders in long-term corticosteroid therapy
Background. In severe dermatoses, corticosteroid drugs are usually prescribed for a long period of time, and even for life; therefore, the detection of side effects caused by prolonged use of systemic glucocorticosteroid...
Adrenal Hypertension: Aspects of Laboratory Examination
The need for a correct choice of managing patients with hypertension is due to the possible development of heart failure and cardiovascular complications. Excluding adrenal pathology is one of the important steps in diag...
Clinical Efficacy of Actovegin in Complex Treatment of Patients with Diabetes Mellitus Type 2 with Diabetic Polyneuropathy Against Arterial Hypertension
The aim of the study — to evaluate the clinical efficacy of Actovegin in complex treatment of patients with diabetes mellitus (DM) type 2 diabetic polyneuropathy (DPN) with arterial hypertension (AH). We observed 53 pati...
Immunomodulatory Therapy of Chronic Fatigue Syndrome Associated with Metabolic Syndromе
In 16 patients with chronic obstructive pulmonary disease with metabolic syndrome and chronic fatigue syndrome, we have studied the effect of combined use of noophen and broncho-munal based on the evaluation of clinical...