Formulation and evaluation of Terbutaline sulphate 5mg controlled release tablets for the treatment of nocturnal asthma
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 4
Abstract
The present work was aimed to design & characterize an oral dosage form to release Terbutaline sulphate following a programmed time period (pulsed release system). Pulsatile release tablet comprises a drug containing core and pH sensitive polymeric coating capable of delaying drug release and providing gastric resistance. The core tablets of Terbutaline sulphate were prepared for the treatment of nocturnal asthma. The core tablets were prepared by direct compression method using different disintegrating agents. The cores were coated with pH sensitive polymers (HPMCK4100, EC) at different coating levels to develop a suitable dosage form which should show minimum drug release in upper regions of gastrointestinal tract (GIT). Prepared tablets were characterized for various physical parameters such as hardness, thickness, weight variation disintegration test drug content and in-vitro drug release characteristics. All the parameters were found to be in the standard range. The dissolution of best formulation F3, have shown the lag phase of 5 hours at 10% coating level and almost complete drug release was achieved after 6 hours. The kinetic study data for best formulation followed zero order kinetics.
Authors and Affiliations
Kishore Babu, Dhatrika Sravanthi
Keywords
Related Articles
- EP ID EP33462
- DOI -
- Views 331
- Downloads 0
Formulation and evaluation of fast dissolving films containing Rizatriptan benzoate
The aim of the present investigation was to develop fast dissolving films of Rizatriptan benzoate using Eudragit EPO, HPMC and PVA. Films of HPMC E5, HPMC E15, PVA and combination of Eudragit EPO and HPMC E5 were prepa...
A new development and validated RP-HPLC method for the assay and related substances of Itraconazole in capsule dosage form
The present investigation reveals about a simple, economic, selective, precise and accurate reverse phase high performance liquid chromatography method for analysis of Itraconazole and Related Substances of Itraconazol...
FORMULATION AND EVALUATION OF BILAYER TABLET OF CONVENTIONAL RELEASE PARACETAMOL AND MODIFIED RELEASE DICLOFENAC SODIUM
The present study deals with formulation and evaluation of bilayer tablet of paracetamol and diclofenac sodium to provide control over release of drug and to maintain the drug concentration. The major ingredients are p...
RP-HPLC method for simultaneous estimation of Candesartan and Amlodipine in bulk and pharmaceutical dosage forms
A simple, rapid, accurate and precise isocratic reversed phase high performance liquid chromatographic method has been developed and validated for simultaneous estimation of Candesartan and Amlodipine in tablet dosage...
NOVEL RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF METFORMIN AND PIOGLITAZONE DRUGS IN PURE AND PHARMACEUTICAL DOSAGE FORMS
The present investigation describes about a simple, economic, selective, accurate, precise reverse phase high performance liquid chromatographic method for the simultaneous estimation of metformin and pioglitazone in p...