Formulation and in vitro, in vivo evaluation of Cefixime controlled Gastroretentive floating drug delivery system
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2017, Vol 6, Issue 2
Abstract
The aim of the present work was to develop and optimize gastroretentive floating system of cefixime (CF) for the effective treatment. The present study was carried out with an objective of preparation and in vivo evaluation of floating tablets of using cefixime as a model drug using Eudragit polymers (Eudragit-S100, Eudragit-RLPO & Eudragit-RSPO) to improve oral bioavailability of cefixime floating tablets by increasing gastric residence time. The tablets were prepared by direct compression method. The effect of polymers concentration and viscosity grades of Eudragit on drug release profile was evaluated. The result of in vitro dissolution study showed that the drug release profile could be controlled by increasing the concentration of Eudragit-RLPO. The optimized formulation (F18) containing Eudragit-RLPO showed 99.24% drug release at the end of 24h. Changing the viscosity grade of EudragitRLPO had no significant effect on drug release profile. The optimized formulations (F18) containing sodium bicarbonate 40mg per tablet showed desired buoyancy (floating lag time of about 20 min and total floating time of >24hr). Optimized formulation (F18) followed diffusion controlled zero order kinetics and fickian transport of the drug. FTIR and DSC studies revealed the absence of any chemical interaction between drug and polymers used. The best formulation (F18) was selected based on in vitro characteristics and was used in vivo radiographic studies by incorporating BaSO4. These studies revealed that the tablets remained in the stomach for 24hrs in fasting human volunteers and indicated that gastric retention time was increased by the floating principle, which was considered desirable for the absorption window drugs. Studies to evaluate the pharmacokinetics in vivo showed better bioavailability, area under the concentration time curve, elimination rate constant and half-life than marketed product.
Authors and Affiliations
E. Sathish Reddy
Keywords
Related Articles
- EP ID EP412893
- DOI -
- Views 111
- Downloads 0
An overview of Depression and its Pharmacotherapy
Depression is a very common mental health disorder, increasing with the socioeconomic and medical condition. Patients experience different feelings, depending upon the severity, frequency, and duration of symptoms. If l...
Astashine capsules: an excellent choice to boost immune system.
Astaxanthin is a naturally occurring carotenoid which is derived from the microalgae Haematococcus pluvialis. As well as being the most powerful antioxidant known to science, it also has potent anti-inflammatory properti...
New Anti-aflatoxin marine and Terrestrial extracts with assessment of their Antioxidants, Antimicrobial, Glycemic and Cholinergic properties bioscreening of new Anti-aflatoxin natural extracts
Aflatoxins are a group of closely related mycotoxins that are widely distributed in nature in different agricultural communities. These toxins can produce a variety of diseases related to liver and brain damage. In this...
Evaluation of Tephrosia purpurea for anti hyperlipidemic activity in high fat induced rats
The anti-hyperlipidemic effect of methanolic extract of leaves of Tephrosia purpurea (T.purpurea) was tested in high fat diet induced hyperlipidemic rat models. Here, chronic hyperlipidemia was induced by feeding fat di...
Bioevaluation of Sirupellai samoolam herbal formulation for Antiurolithiatic activity
Ayurveda offers vast scope for the successful treatment of urolithiasis. Although most remedies were herbal and proved useful, a systematic scientific evaluation has been reported for only few remedies. Sirupeelai samoo...