MDM2 promoter polymorphism (rs2279744) and serum estrogen level are associated with increased risk of epithelial ovarian cancer: A case-control study
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 4
Abstract
Introduction Epithelial ovarian cancer EOC is most common malignancy affecting Indian women One of the transcriptional targets of p53 is human homolog of Murine Double Minute 2 Oncogene MDM2 which is a crucial negative regulator of p53 Polymorphism in intronic promoter P2 region of MDM2 at position 309 increase binding affinity of specific protein 1 lead to over expression of MDM2 and deflation of p53 pathway The objectives of study were to find effect of MDM2 SNP309 TG polymorphism and serum estrogen level on risk of development of EOC and interaction between MDM2 SNP309 TG and TP53 72 ArgPro polymorphismMaterials and Methods Eighty EOC cases and eighty age matched healthy controls were included in study MDM2 SNP309 TG polymorphism was detected by ASOPCR technique and serum estrogen levels were detected by chemiluminescence immunoassayResult MDM2 SNP309 GG genotype was associated with significantly increased risk OR 286 95 CI 107766 P003 and early age onset P0001 of EOC Serum Estrogen was significantly PG and TP53 72ArgPro gene polymorphism act additively in developing ovarian cancerConclusion This study provides evidence that MDM2 SNP309 TG promoter polymorphismin association with the higher serum estrogen levels is associated with genetic susceptibility and early age onset of ovarian cancerKeywords Epithelial ovarian cancer MDM2 TP53 Estrogen
Authors and Affiliations
Sagar Dholariya, Sohil Takodara, Rashid Mir, Alpana Saxena
Keywords
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- EP ID EP475424
- DOI 10.18231/2394-6377.2018.0112
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