Mucoadhesive: As Oral Controlled Gastroretentive Drug Delivery System
Journal Title: International Journal of Research in Pharmacy and Science - Year 2012, Vol 2, Issue 3
Abstract
Mucoadhesion is a field of current interest in the design of drug delivery systems. Mucoadhesive drug delivery system prolong the residence time of the dosage form at the site of application or absorption and facilitate an intimate contact of the dosage form with the underline absorption surface and thus contribute to improved and / or better therapeutic performance of the drug. In recent years many such mucoadhesive drug delivery systems have been developed for oral, buccal, nasal, rectal and vaginal routes for both systemic and local effects. In this paper main prominence on gastrointestinal dosage forms along with concepts, mechanism of mucoadhesion, factors affecting mucoadhesion, permeation enhancers and evaluation methods and also some review regarding research work already been carried. An overview of the last decade’s discoveries on mucoadhesion and applications of mucoadhesive as drug carriers is given. Mucoadhesive drug delivery systems with its various advantages have a lot of potential in formulating dosage forms for various chronic diseases.
Authors and Affiliations
Pratima Nikalje Anna, Shailee Tiwari , Kamble Smrutigandha
Keywords
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