DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE ESTIMATION OF CEFTAROLINE FOSAMIL IN BULK AND INJECTION FORM
Journal Title: Int J of Pharm Res & Analy - Year 2012, Vol 2, Issue 2
Abstract
Two simple, sensitive, specific, spectrophotometric methods have been developed for the determination of ceftaroline fosamil in bulk and Injection forms. The λmax of ceftaroline fosamil was found to be 245.2 nm in distilled water. The zero order UV Spectrophotometric method exhibits high sensitivity, with linearity and obeys beer’s law in the range of 2 – 10 μg/mL. The limit of detection and quantification were found to be 0.231 μg/mL and 0.7019 μg/mL respectively. While area under curve for zero order spectrum of ceftaroline fosamil was measured from 235 – 255 nm which obeys Beer’s law in the concentration range of 2 – 10 μg/mL. These methods were fully validated according to ICH guidelines. The LOD and LOQ were found to be 0.223μg/mL and 0.669 μg/m, respectivelyL. Hence it could be concluded that the proposed methods would be suitable for the analysis of ceftaroline fosamil in bulk and pharmaceutical preparations
Authors and Affiliations
A. Suneetha , China Venkanna , S. Kathirvel
Keywords
Related Articles
- EP ID EP137045
- DOI -
- Views 108
- Downloads 0
AN OVERVIEW ON HIGH PERFORMANCE CAPILLARY ELECTROPHORESIS
ABSTRACT High performance Capillary electrophoresis (HPCE) is a separation technique in which the analytes are separated on the basis of differences in their charge-to-size ratios. This makes HPCE especially suit...
ANALYTICAL TECHNIQUES FOR THE ESTIMATION OF MELOXICAM IN BULK AND PHARMACEUTICAL DOSAGE FORMS: A REVIEW
Meloxicam is 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide is an selective to cyclooxygenase-2 (Cox-2) inhibitor and used in analgesic, antipyretic activities belongs to...
FORMULATION AND EVALUATION OF SULPHAMETHOXAZOLE SUSPENSION BY PH CHANGE METHODS
Dispersed phase preparation is an important step in the formulation of suspensions. One of the good criteria for suspension is fine (micron) sized dispersed phase particles. Fine size of the particles in a suspension is...
A NEW METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF ELETRIPTAN BY USING RP-HPLC METHOD
A simple, rapid, specific, accurate and precise reverse phase high performance liquid chromatographic method was developed for estimation of eletriptan in tablet dosage form. Chromatographic separation was carried out by...
RP-HPLC METHOD DEVELOPMENT & VALIDATION FOR SIMULTANEOUS ESTIMATION OF TRITHIOPARAMETHOXYPHENYL PROPANE (ANETHOLE TRITHIONE) AND CHLORPHENIRAMINE MALEATE IN TABLET DOSAGE FORM
ABSTRACT A Simple, precise and rapid RP-HPLC method was developed and validated for simultaneous Estimation of Trithiparamethoxyphenyl propene (Anetholetrithione) and Chlorpheniramine Maleate in tablet dosage form....