Onco-pathological correlation of hormonal receptors and Her2 neu expression in breast cancer
Journal Title: Medpulse International Journal of Pathology - Year 2017, Vol 1, Issue 2
Abstract
Background: Breast cancer is a complex genetic disease characterized by the accumulation of multiple molecular alterations. Hormone receptor studies such as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2/neu) are routinely done in breast carcinoma. It not only helps in the prognosis of the tumor but also helps in deciding its treatment. Objectives: To study the Histopathological diagnosis and their ER, PR and Her2/neu receptor status of breast carcinoma and to assess the hormone receptor status and HER2/neu by immunohistochemistry. Results: Out 65 cases 36 (55.38%) cases showed ER positive and remaining 29 (44.61%) showed negative. Similarly for PR, 26 (40%) cases showed positive and 39 (60%) turned out to be negative. 33 (50.76%) cases showed negative for Her2 neu staining, whereas 7 (10.76%) showed +1, 19(29.23%) showed +2 and 6 (9.23%) displayed +3. Conclusion: Tumors that express both ER and PR have the greatest benefit from hormonal therapy, and those containing only ER or only PR still have significant response. HER2/neu has its role as a prognostic indicator and as a predictor of response to Trastuzumab (Herceptin) therapy in breast cancer patients.
Authors and Affiliations
Shashidhar M R, Priyanka P Shetty
Keywords
Related Articles
- EP ID EP209990
- DOI -
- Views 124
- Downloads 0
Diagnostic role of mean platelet volume in cases presenting with thrombocytopenia in a tertiary health care setting of Puducherry
Background: Platelet are membrane bound discoid structure that plays a crucial role in hemostasis. Thrombocytopenia is the reduction in the peripheral blood platelet count below150000 / mm3 after control of preanalytical...
A clinicopathological study of 48 cases of lupus nephritis
Background: Systemic lupus erythematosus is a multi-systemic disorder which commonly affects the kidneys and remains the most dangerous life threatening complication.1Renal manifestationsare highly variable and patients...
Clinico-pathological study of male breast lesions
Background: Male breast lesions are less common than female breast lesions, which include non-neoplastic inflammatory, benign and malignant neoplastic lesions. Aim: To study the clinico-pathological characteristics of br...
Cytomorphological study of lymph node lesions at tertiary care centre
Background: The degree and pattern of morphological changes in lymphadenopathy are dependent on the inciting stimulus and the intensity of the response. FNAC of lymph node has become an integral part of the initial diagn...
Cyto-histopathological spectrum of palpable breast lesions presenting in rural based medical college and hospital at Warudi, Jalna (Maharashtra) India
Benign as well as malignant breast lesions are quite common in Indian population. Breast is second most common cancer site after cancer cervix in Indian females. Currently, 75,000 new cases of breast cancer are detected...