Oxidative stress in post menopausal women with cardiovascular risk factors
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2016, Vol 3, Issue 1
Abstract
Background: Menopause is a normal occurrence in the life of every woman. As the life expectancy of woman all over the world now increases, a woman has to spend almost 1/3rd of her life in menopause years. Along with the increase in life expectancy the cardiovascular disease is increasing. Objectives: To study the association between oxidative stress and various cardiovascular risk factors in post-menopausal women. Methods: 50 postmenopausal women with cardiovascular risk factors like hyperglycemia, hypertension, high Body Mass Index and Hyperlipidaemia were selected as cases and compared with 50 age matched apparently healthy controls. Malon-di-aldehyde (MDA) was taken as the marker for oxidative stress and vitamin E & vitamin C were taken to assess antioxidant status. Student’s t-test was applied to compare different parameters between the groups and Pearson’s correlation was applied to see the correlation with different parameters in the case group. Results: It was found that MDA values in postmenopausal women with cardiovascular risk factors were significantly higher as compared to the post menopausal women without cardiovascular risk factors (p < 0.001). There is significant decrease in vitamin E and C values in cases (p is < 0.001 and < 0.01 respectively). Comparing the various oxidative markers in cases and control it was found that MDA values have a significant negative correlation with vitamin E and C (r= -0.4 and r= -0.7 respectively). Whereas correlation between changes in Vitamin E and vitamin C was positive but not significant (r= +0.2, p ˃0.05). Conclusion: Antioxidant medication and other measures can be adopted to reduce oxidative stress in post menopausal women with cardiovascular risk factors and reduce the morbidity and mortality associated with cardiovascular disease.
Authors and Affiliations
Subrat Kumar Tripathy, Viyatprajna Acharya, Sarthak Ranjan Nayak, Pramila Kumari Mishra
Keywords
Related Articles
- EP ID EP242140
- DOI -
- Views 127
- Downloads 0
Study of specimen stability for biochemical parameters
Introduction: The blood sample is collected and transported to the laboratory for analysis, during this time the samples bares many extra-analytical factors prior to analysis. Contact time of plasma or serum with the blo...
Six sigma in clinical biochemistry: It matters, measure it
Introduction: Accurate test results are the core of healthcare system since physician's decisions mostly depends on the laboratory results. The evaluation of laboratory performance is critical to maintain accurate labora...
Serum ferritin level in type 2 diabetes mellitus - A case control study
Background: Hyperferritinemia probably contributes insulin resistance and subsequently to decreased insulin secretion causes for development of insulin resistance. Objectives: Compare HbA1c with Ferritin and find correla...
Olive Oil in Indian Kitchen: a Food for Thought, a Thought for Food
Background and Objective: Role of dietary fat in aetiopathogenesis of modern epidemics like CHD, Hypertension, DM and metabolic syndrome is undeniable. PUFA and MUFA- rich edible oils are in recent trend, which are repla...
Reliability of blood gas analyzer for the measurement of electrolytes - A comparative study
Background: Electrolyte and blood gas analysis are essential for most patients who are admitted in the casualty. Routinely simultaneous arterial and venous sample would be sent to the laboratory for blood gas analysis an...