Pharmacological studies of anti-diarrhoeal activity of Guettarda speciosa (L.)in experimental animals.
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 2
Abstract
Aims: The purpose of the present study was to evaluate scientifically the anti-diarrhoeal effects of ethanolic (90%) extract of inner bark of Guettarda speciosa. Linn (EEGS) was studied against castor oil-induced-diarrhoea model in rats. Methods: Antidiarrhoeal activity of 90% ethanol extract of Guettarda speciosa was investigated in this study using castor oil-induced-diarrhoea, enteropooling and Small intestinal transit models in rats. The weight and volume of intestinal content induced by castor oil were studied by enteropooling method. Results: Standard drug diphenoxylate (5 ml/kg, p.o) was significant reductions in fecal output and frequency of droppings whereas EEGS at the doses of 200 and 400 mg/kg p.o significantly (P<0.001) reduced the castor-oil induced frequency and consistency of diarrhoea and enteropooling. The gastrointestinal transit rate was expressed as the percentage of the longest distance travelled by the charcoal divided by the total length of the small intestine. EEGS at the doses of 200 and 400 mg/kg significantly inhibited (P<0.001) the castor oil induced charcoal meal transit. Conclusion: The EEGS showed marked reduction in the number of diarrhoea stools and the reduction in the weight and volume of the intestinal contents, as well as a modest reduction in intestinal transit. The results obtained establish the efficacy and substantiate the folklore claim as an anti- diarrheal agent. Further studies are needed to completely understand the mechanism of anti-diarrhoeal action of Guettarda speciosa.
Authors and Affiliations
Gandhimathi R, Saravana Kumar A, Senthil Kumar K. K, Kusuma Praveen Kumar , Uma Maheswari J
Keywords
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