Phytochemical profiling, antimicrobial and cytotoxicity studies of methanolic extracts from Ruta graveolens
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 5
Abstract
Aim of study: Ruta graveolens is found to have potential value in traditional medicine its components are of great interest in medicinal chemistry. It contains many active principles that act as antioxidants and possess anticancer, antiviral and antimicrobial properties. The present study deals with quantitative and qualitative studies of phytochemicals in Ruta graveolens including GC-MS profiling of the methanolic extracts of stem, root and leaves. The antimicrobial and anticancer activities are also reported. Results: Qualitative and quantitative studies revealed that extracts from different parts of Ruta graveolens showed variation of phytochemical components that included alkaloids, flavonoids, phenols and tannins. GC-MS profiling lead to the identification of more than 160 phytochemicals. The extracts were also found to have microbe inhibiting activities from different regions (stem, root and leaf) and potential cytotoxic activities with a lethal concentration of 62 μg against Hep2 cell lines. Conclusion: The present study has opened avenues in the field of purification of active components of plants. Characterization of these compounds may find potential applications in pharmaceutical and drug industry. Further studies may also aim in the screening of this plant for antiviral activity against HIV and other dreadful diseases.
Authors and Affiliations
Benazir J. F, Suganthi R, Renjini Devi M. R, Suganya K, Monisha K, Nizar Ahamed K. P, Santhi R.
Keywords
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