Preclinical evaluation of anti-cancer effect of naringenin in 7, 12-dimethyl benzanthracene induced breast cancer in female rats
Journal Title: Medpulse International Journal of Pharmacology - Year 2018, Vol 8, Issue 2
Abstract
Background: The present study is aimed to screen the anti-cancer effect of naringenin in 7,12-dimethyl benzanthracene induced breast cancer in female Wistar albino rats. Methodology: The study was conducted in the Division of Pharmacology, Annamalai University, Tamil Nadu. Female Wistar Albino rats weighing 140-150gm were selected in this study. All the animals were kept in Central Animal House under standard conditions. Total 36 rats were divided into six groups, each of 6 rats. G-1 (Control), G-2- (7,12-Dimethyl benzanthracene (25mg/kg/BW/sc), G-3 (7,12-Dimethyl benzanthracene(25mg/kg/sc)+Vincristine(500µg/kg/BW/ip),G-4(7,12-Dimethylbenzanthracene(25 g/kg/sc)+Naringenin (50 mg/kg/BW/PO), G-5 (7,12-Dimethyl benzanthracene (25 mg/kg/sc)+Naringenin (100 mg/kg/BW/PO) and G-6 (7,12-Dimethyl benzanthracene (25 mg/kg/sc)+Naringenin (200 mg/kg/BW/PO). Inducing drug was administered only once. All the drugs were given upto 16 weeks. At the end of study period rats were sacrificed. The breast tissue was insolated and used for estimation of anti-oxidant enzymes like TBARS, Super oxide dismutase, Catalase, Glutathione and Glutathione peroxidase. Results: Group-2 showed significant changes compared to group-1. Group-3 and 5 showed significant difference compared to Group-2. Group-5 did not show significant difference compared to Group-3 in TBARS, super oxide disumutase, catalase, glutathione and glutathione peroxidase enzymes. Conclusion: Naringenin showed significant dose dependent anti-cancer effect in this study.
Authors and Affiliations
Sandeep V M, Nirmala P, Sarath Babu K
Keywords
Related Articles
- EP ID EP471396
- DOI 10.26611/1010822
- Views 97
- Downloads 0
Safety profile of atorvastatin in post myocardial infarction and post stroke patients
Background: The side effects of high dose atorvastatin treatment in post myocardial infarction and post stroke patients have not been studied in detail. The present work aim to study whether the toxicity profile of atorv...
A study of drug utilization pattern of analgesics in postoperative patients of tertiary care hospital
Background and Objectives: Postoperative pain is the pain developed after surgical trauma and due to inflammatory reaction. Analgesic prescribed to postoperative patients differ with different patients, as pain is subjec...
A study of patient related barriers affecting effective treatment of asthma
Background: Drugs play an important role in improving human health and promoting well-being. However, to produce the desired effect, they have to be safe, efficacious and have to be used rationally. Aims and Objectives:...
Comparative study of antiulcer drug in allopathic medicine (omeprazole) with Siddha medicine (Astathy Chooranam, Sangu Parpam) in the management of gastric ulcer
Background: Among different disorders of the gastrointestinal system, the gastric ulcer is the one which is more prevalent and have a greatest clinical impact. The most commonly used as anti-ulcer drugs are H-2 blockers...
Effect of glimepride and metformin as a monotherapy on lipid profile in T2DM patients
Aims and Objective: To compare effect of glimepride and metformin alone on lipid profile in T2DM patients Material and Methods: T2DM patients having duration of less than 5 years were randomly selected and grouped in to...