Preclinical evaluation of hypolipidemic effect of hesperidin in high cholesterol diet model in wistar albino rats
Journal Title: Medpulse International Journal of Pharmacology - Year 2019, Vol 10, Issue 1
Abstract
Background:Hyperlipidemia is a major cause of various coronary heart diseases. Early diagnosis and initiation treatment can reduce the mortality. The present study aimed to evaluate the hypolipidemic effect of hesperidin in high cholesterol rats. Materials and Methods: Wister Albino rats weighing 200-250gm were used in this study. 24 rats were divided into four groups each of 6 rats. G-I (Normal diet), G-II (High cholesterol diet), G-III (High cholesterol diet + Hesperidin 100 mg/kg) and G-IV (High cholesterol diet + Hesperidin 200 mg/kg). Four groups tetrad with respective drugs for 90 days. At the end of experiment blood and hepatic samples were collected and used for estimation of total cholesterol, triglycerides, HDL, LDL and VLDL. SPSS software used for statistical analysis. Data was expressed in mean and standard deviation. Results: Group-I showed significant effect in lipid profile compared to group-II. Group-III and IV showed significant results in lipid profile compared to Group-I and II. Group-IV showed better effect than group-III. Similar effects were observed in hepatic lipid profile. Conclusion: Animals treated with hesperidin showed significant effect on blood and hepatic lipid profile. From the study results it can be concluded that hesperidin can be used in the prevention and treatment of hyperlipidemia.
Authors and Affiliations
Pradeep Kumar V, Vijai Sundar E
Keywords
Related Articles
- EP ID EP615741
- DOI -
- Views 106
- Downloads 0
A study of patient related barriers affecting effective treatment of asthma
Background: Drugs play an important role in improving human health and promoting well-being. However, to produce the desired effect, they have to be safe, efficacious and have to be used rationally. Aims and Objectives:...
A study of drug utilization pattern of analgesics in postoperative patients of tertiary care hospital
Background and Objectives: Postoperative pain is the pain developed after surgical trauma and due to inflammatory reaction. Analgesic prescribed to postoperative patients differ with different patients, as pain is subjec...
Safety profile of atorvastatin in post myocardial infarction and post stroke patients
Background: The side effects of high dose atorvastatin treatment in post myocardial infarction and post stroke patients have not been studied in detail. The present work aim to study whether the toxicity profile of atorv...
Preclinical evaluation of anti-cancer effect of naringenin in 7, 12-dimethyl benzanthracene induced breast cancer in female rats
Background: The present study is aimed to screen the anti-cancer effect of naringenin in 7,12-dimethyl benzanthracene induced breast cancer in female Wistar albino rats. Methodology: The study was conducted in the Divisi...
Efficacy and safety of oral fluconazole vs topical antifungal imidazoles in tinea corporis: A comparative therapeutic trial
Background:Dermatophytes are the most common causes of superficial fungal infections worldwide. All dermatophytosis of glabrous skin except the palms, soles and groin are categorized under tinea corporis. Dermatophytic i...